The invention relates to the daily use chemical filed and the pharmaceuticals industry, in particular to chitosan sulfate schiff base and a synthetic method of chitosan sulfate schiff base. Chitosan sulfate schiff base is obtained by carrying sulfuric acid esterification on chitosan, and reacting amino in product obtained after sulfuric acid esterification with protocatechualdehyde to obtain chitosan sulfate schiff base shown in a formula (1), the obtained chitosan sulfate schiff base is soluble to water, strengthens biological activity of chitosan, has synergistic effects, expands application scope of chitosan and can be widely used in the daily use chemical filed such as medicines.
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