The invention specifically relates to application of a halogenated indole and derivatives thereof as a marine antifouling agent, belonging to the technical field of marine antifouling paints. The invention provides application of one or more selected from the group consisting of halogenated indole and derivatives thereof as the marine antifouling agent. According to the invention, the halogenated indole compounds can inhibit attachment of marine stained microbes, marine algae and large-scale marine stained animals and presents high-efficiency and wide-spectrum antifouling activity. The halogenated indole compounds extensively exist in marine organisms, are easy to biodegrade and have low toxicity and no pollution; a marine antifouling agent prepared from the halogenated indole compounds does not contain heavy metals and causes no harm to the environment. Moreover, an artificial synthetic method for the halogenated indole compounds is simple, which facilitates application of the halogenated indole compounds in marine antifouling paints.
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