| 一种两亲性C-6-(4-(甲基氨基)-1, 2, 3-三氮唑)脱氧菊糖衍生物及其制备和应用 |
| 其他名称 | A kind of amphiphilic C-6 - (4 - (methylamino) - 1, 2, 3-triazole) deoxy alantin derivatives and their preparation and use
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| 专利类型 | 发明
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| 专利号 | 2013101534694
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| 郭占勇 ; 任剑明; 胡云霞; 冯艳; 董方; 李青
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| 专利权人 | 中国科学院烟台海岸带研究所
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| 申请日期 | 2013-04-28
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| 2016-03-16
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| 专利状态 | 授权
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| 授权国家 | 中国
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| 摘要 | 本发明涉及一种两亲性C-6-(4-(甲基氨基)-1, 2, 3-三氮唑)脱氧菊糖衍生物及其制备和应用。两亲性C-6-(4-(甲基氨基)-1, 2, 3-三氮唑)脱氧菊糖衍生物式(1)所示，n的平均取值范围是10－35。将原料菊糖的伯羟基经卤代, 其它位羟基经酰基保护后，与叠氮钠或叠氮锂在40-70℃条件下反应8－24h，经纯化得6叠氮-3, 4-二酰基-6脱氧菊糖，6叠氮-3, 4-二酰基-6脱氧菊糖与丙炔胺经click chemistry反应得两亲性C-6-(4-(甲基氨基)-1, 2, 3-三氮唑)脱氧菊糖衍生物；所述叠氮钠或叠氮锂的摩尔量是原料菊糖的1至2倍；丙炔胺与原料菊糖摩尔量的比为2-3 : 1。本发明产品可广泛用且合成步骤简单，易于推广，所需设备及原料易得。 |
| 其他摘要 | The invention relates to amphiphilic C-6-(4-(methyl amino)-1, 2, 3-triazole)deoxidized inulin derivatives and a preparation and an application thereof. The amphiphilic C-6-(4-(methyl amino)-1, 2, 3-triazole)deoxidized inulin derivatives are as shown in formula (1), wherein n has an average range of 10-35. The preparation method comprises the following steps : halogenating the primary hydroxyl group of raw material inulin, performing acyl protection of hydroxy groups at the other sites, allowing the inulin to react with sodium azide or lithium azide at 40-70 DEG C for 8-24 hours, performing purification to obtain 6-azido-3, 4-diacyl-6-deoxidized inulin, allowing the 6-azido-3, 4-diacyl-6-deoxidized inulin to react with propynylamine through a click chemistry reaction to obtain the amphiphilic C-6-(4-(methyl amino)-1, 2, 3-triazole)deoxidized inulin derivatives. The mole amount of the sodium azide or lithium azide is 1-2 times as many as the that of the raw material inulin; the mole ratio of the propynylamine to the raw material inulin is 2-3 : 1. The product of the invention is wide in application, simple in synthetic steps, easy to popularize, and easily available in required equipment and raw materials. |
| 申请号 | 2013101534694
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| 公开（公告）号 | CN103694377B
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| IPC 分类号 | C08B37/18
; A01N43/647
; A01P1/00
; A61K31/733
; A61P31/04
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| 专利代理人 | 周秀梅
; 李颖
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| 代理机构 | 沈阳科苑专利商标代理有限公司 21002
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| 文献类型 | 专利
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| 条目标识符 | http://ir.yic.ac.cn/handle/133337/33996
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| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
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| 作者单位 | 中国科学院烟台海岸带研究所
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推荐引用方式
GB/T 7714 |
郭占勇,任剑明,胡云霞,等. 一种两亲性C-6-(4-(甲基氨基)-1, 2, 3-三氮唑)脱氧菊糖衍生物及其制备和应用. 2013101534694[P]. 2016-03-16.
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