The invention relates to a fluorescence probe, in particular to an organic compound for detecting histamine on the basis of cyanine fluorophores and an application of the organic compound. The compound is the organic compound based on cyanine, and the structural formula is represented as formula I in the description. According to the fluorescence probe, fluorescence emission wavelength and strength both change in the presence of histamine, and the fluorescence probe can be applied to detection of bioactive histamine. Background interference of an external environment is greatly reduced on thebasis of near-infrared spectral characteristics of the compound, and detection sensitivity is improved by ratio fluorescence detection. The compound serving as the fluorescence probe can be applied tohistamine detection of cells and complex biological samples and has great biomedical significance for studying dynamics mechanism of histamine production and accumulation and cell signaling transduction and discovering fluctuation conditions and actions of histamine content in diseases.
; 张霞; 于法标; 高敏; 黄严
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