The present invention relates to the field of marine chemical engineering technology, and is especially one kind of chitosan hydrochloride containing sulfhydryl acid salt and its preparation process and application. The structural formula of chitosan hydrochloride containing thiolate is as follows, where R is, and the average value range of n is 50-100. The preparation method has the advantages that sulfhydryl groups are introduced into the chitosan, so that the improved chitosan has good antioxidant activity; and meanwhile, the preparation process is simple and quick, is carried out in a water system in the whole process, and almost has no side reaction. Experimental research shows that the derivative has high water solubility and high antioxidant activity, and may be used in medicine, food, health product, agriculture and other fields.
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