Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe

doi:10.1039/d3tb00893b

	Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe
	Han, Xiaoyue 1; Xing, Yanlong 2,3; Song, Xinyu 4; Dou, Kun 2,3; Yu, Fabiao 2,3; Chen, Lingxin1
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B
ISSN	2050-750X
	2023-05-23
页码	9
DOI	10.1039/d3tb00893b
通讯作者	Xing, Yanlong([email protected]) ; Yu, Fabiao([email protected]) ; Chen, Lingxin([email protected])
英文摘要	Reliable biomarkers are crucial for early diagnosis of diseases and precise therapy. Biological thiols (represented by glutathione, GSH) play vital roles in the antioxidant defense system for maintaining intracellular redox homeostasis in organisms. However, the aberrant variation in the cellular concentration of GSH correlates with diverse diseases including cancer. Here, a ratiometric near-infrared fluorescent probe CyO-Disu is constructed for the specific sensing of GSH variation in live cells and mice models of hepatic carcinoma (HCC). CyO-Disu features three key elements, a response moiety of bis(2-hydroxyethyl) disulfide, a near-infrared fluorescence signal transducer of heptamethine ketone cyanine, and a targeting moiety of d-galactose. By virtue of its liver-targeting capability, CyO-Disu was utilized for evaluating GSH fluctuations in primary and metastatic hepatoma living cells. To evaluate the efficacy of CyO-Disuin vivo, orthotopic HCC and pulmonary metastatic hepatoma mice models were employed for GSH imaging using two-dimensional and three-dimensional fluorescence molecular tomographic imaging systems. The bioimaging results offered direct evidence that GSH displayed varied concentrations during the progression of HCC. Therefore, the as-synthesized probe CyO-Disu could serve as a potential powerful tool for the early diagnosis and precise treatment of HCC using GSH as a reliable biomarker.
资助机构	National Natural Science Foundation of China ; Hainan Province Science and Technology Special Fund ; Hainan High-Level Talents Project ; Nanhai Young-Talent Program of Hainan ; Hainan Province Clinical Medical Center (2021) ; Natural Science Research Talent Project of Hainan Medical University ; Guangzhou Fundamentals and applied fundamentals project ; Project for Functional Materials and Molecular Imaging Science Innovation Group of Hainan Medical University
收录类别	SCI
语种	英语
关键词[WOS]	SYSTEM ; CELLS
研究领域[WOS]	Materials Science
WOS记录号	WOS:001019763100001
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33349
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Xing, Yanlong; Yu, Fabiao; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Hainan Med Univ, Affiliated Hosp 1, Key Lab Hainan Trauma & Disaster Rescue, Haikou 571199, Peoples R China 3.Hainan Med Univ, Engn Res Ctr Hainan Biosmart Mat & Biomed Devices, Key Lab Hainan Funct Mat & Mol Imaging, Coll Emergency & Trauma,Key Lab Emergency & Trauma, Haikou 571199, Peoples R China 4.Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis,Affiliated Hosp 1, Guangzhou 510120, Peoples R China
推荐引用方式 GB/T 7714	Han, Xiaoyue,Xing, Yanlong,Song, Xinyu,et al. Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe[J]. JOURNAL OF MATERIALS CHEMISTRY B,2023:9.
APA	Han, Xiaoyue,Xing, Yanlong,Song, Xinyu,Dou, Kun,Yu, Fabiao,&Chen, Lingxin.(2023).Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe.JOURNAL OF MATERIALS CHEMISTRY B,9.
MLA	Han, Xiaoyue,et al."Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe".JOURNAL OF MATERIALS CHEMISTRY B (2023):9.