Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis

doi:10.1016/j.marenvres.2022.105839

	Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis
	Wang, Shuang 1,2,3; Sun, Zuodeng 5; Ren, Chuanbo 4; Li, Fei1 ; Xu, Yingjiang 4; Wu, Huifeng1 ; Ji, Chenglong1
发表期刊	MARINE ENVIRONMENTAL RESEARCH
ISSN	0141-1136
	2023
卷号	183 页码:10
关键词	Tetrabromobisphenol A Detoxification Reproductive endocrine disruption Sulfation Mytilus galloprovincialis
DOI	10.1016/j.marenvres.2022.105839
通讯作者	Ji, Chenglong([email protected])
英文摘要	As a typical brominated flame retardant (BFR), tetrabromobisphenol A (TBBPA) has been frequently detected in both biotic and abiotic matrices in marine environment. Our previous study found that genes related to metabolism phase I/II/III as well as steroid metabolism in Mytilus galloprovincialis were significantly altered by TBBPA treatment. However, the time- and dose-dependent response profiles of these genes to TBBPA exposure were rarely reported. In this study, the time- and dose-dependent effects of TBBPA on detoxification and reproductive endocrine disruption in M. galloprovincialis were explored by evaluating the responses of related gene expressions, enzymatic activities and gametogenesis to different concentrations of TBBPA (0.6, 3, 15, 75 and 375 mu g/L) for different durations (14, 21 and 28 days). The results showed that the TBBPA accumulation increased linearly with the increases of exposure time and dose. Cytochrome P450 family 3 (CYP3A1-like) cooperated with CYP4Y1 for phase I biotransformation of TBBPA in mussels. The dose-response curves of phase II/III genes (glutathione-Stransferase (GST), P-glycoprotein (ABCB), and multidrug resistance protein (ABCC)) showed similar response profiles to TBBPA exposure. The common induction of phase I/II/III (CYPs, GST, ABCB and ABCC) suggested TBBPA detoxification regulation in mussels probably occurred in a step-wise manner. Concurrently, direct sulfation mediated by sulfotransferases (SULTs) on TBBPA was also the vital metabolic mechanism for TBBPA detoxification, which was supported by the coincidence between up-regulation of SULT1B1 and TBBPA accumulation. The significant promotion of steroid sulfatase (STS) might result from TBBPA-sulfate catalyzed by SULT1B1 due to its chemical similarity to estrone-sulfate. Furthermore, the promotion of gametogenesis was consistent with the induction of STS, suggesting that STS might interrupt steroids hydrolysis process and was responsible for reproductive endocrine disruption in M. galloprovincialis. This study provides a better understanding of the detoxification and endocrine-disrupting mechanisms of TBBPA.
资助机构	National Natural Science Foundation of China ; Yantai Science and Technology Development Plan
收录类别	SCI
语种	英语
关键词[WOS]	BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; GENE-EXPRESSION ; BIOTRANSFORMATION ; METABOLISM ; RESPONSES ; EXPOSURE ; TISSUE ; BIOACCUMULATION ; ANTIOXIDANT
研究领域[WOS]	Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
WOS记录号	WOS:000911308900003
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32544
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Ji, Chenglong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, YICCAS,CAS Key Lab Coastal Environm Proc & Ecol Re, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 4.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China 5.Shandong Fisheries Dev & Resource Conservat Ctr, Jinan 250013, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shuang,Sun, Zuodeng,Ren, Chuanbo,et al. Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis[J]. MARINE ENVIRONMENTAL RESEARCH,2023,183:10.
APA	Wang, Shuang.,Sun, Zuodeng.,Ren, Chuanbo.,Li, Fei.,Xu, Yingjiang.,...&Ji, Chenglong.(2023).Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis.MARINE ENVIRONMENTAL RESEARCH,183,10.
MLA	Wang, Shuang,et al."Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis".MARINE ENVIRONMENTAL RESEARCH 183(2023):10.