Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves

doi:10.1016/j.scitotenv.2022.160164

	Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves
	Zhan, Junfei 1; Sun, Tao 2; Wang, Xuehong 1; Wu, Huifeng2 ; Yu, Junbao1
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
	2023-02-10
卷号	859 页码:10
关键词	Adaptive mechanism Dose -response Marine bivalves Toxicological endpoints Trace metal
DOI	10.1016/j.scitotenv.2022.160164
通讯作者	Wu, Huifeng([email protected]) ; Yu, Junbao([email protected])
英文摘要	Cadmium (Cd) is a typical pollutant in marine environment. Increasing studies have focused on the toxicological effects of Cd in marine bivalves. However, there were many conflicting findings of toxicological effects of Cd in marine bivalves. An integrated analysis performed on the published data of Cd toxicity in marine bivalves is still absent. In this study, a meta-analysis was performed on the toxic endpoints in bivalves exposed to aqueous-phase Cd from 87 studies screened from 1519 papers. Subgroup analyses were conducted according to the categories of species, tissue, exposure dose and duration. The results showed significant species-, duration-and dose-dependent responses in bivalves to aqueous-phase Cd exposure. In details, clams were more sensitive to Cd than oysters, mussels and scallops, indicated by the largest effect size in clams. Gill, hepatopancreas and hemolymph were top three tissues used to indicate Cd-induced toxicity and did not present a significant tissue-specific manner among them. With regard to toxicological ef-fect subgroups, oxidative stress and detoxification were top two subgroups indicating Cd toxicities. Detoxification and genotoxicity subgroups presented higher response magnitudes. What is more, toxicological effect subgroups presented multiple dose-and duration-dependent curves. Oxidative stress and genotoxicity related endpoints presented signifi-cant increase trends with Cd exposure dose and were preferable biomarkers to marine Cd pollution. Detoxification and energy metabolism related endpoints showed inverted U-shaped and U-shaped dose-response curves, both of which could be explained by hormesis. The linear decrease in oxidative stress and energy metabolism related end-points over time suggested their involvement into the adaptive mechanism in bivalves. Overall, this study provided not only a better understanding the responsive mechanisms of marine bivalves to Cd stress, but also a selection reference for biomarkers to aqueous-phase Cd pollution in marine environment.
资助机构	Key Program from the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province ; Shandong Provincial Natural Science Foundation, China ; Key Program from the National Natural Science Foundation of China
收录类别	SCI
语种	英语
关键词[WOS]	VIRGINICA GMELIN BIVALVIA ; OXIDATIVE STRESS ; CRASSOSTREA-GIGAS ; GIRONDE ESTUARY ; EASTERN OYSTERS ; HEAVY-METALS ; MUSSEL ; RESPONSES ; TOLERANCE ; PROTEINS
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000898837900005
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32471
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Wu, Huifeng; Yu, Junbao
作者单位	1.Ludong Univ, Inst Adv Study Coastal Ecol, Key Lab Ecol Restorat & Conservat Coastal Wetlands, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Junfei,Sun, Tao,Wang, Xuehong,et al. Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,859:10.
APA	Zhan, Junfei,Sun, Tao,Wang, Xuehong,Wu, Huifeng,&Yu, Junbao.(2023).Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves.SCIENCE OF THE TOTAL ENVIRONMENT,859,10.
MLA	Zhan, Junfei,et al."Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves".SCIENCE OF THE TOTAL ENVIRONMENT 859(2023):10.