Alginate oligosaccharide ameliorates azithromycin-induced gut microbiota disorder via Bacteroides acidifaciens-FAHFAs and Bacteroides-TCA cycle axes

doi:10.1039/d2fo02812c

	Alginate oligosaccharide ameliorates azithromycin-induced gut microbiota disorder via Bacteroides acidifaciens-FAHFAs and Bacteroides-TCA cycle axes
	Yan, Shuling 1,2; Zhu, Yanhong 3; Li, Lili1 ; Qin, Song1 ; Yuan, Jingyi 1; Chang, Xiulian 4; Hu, Shanliang 5
发表期刊	FOOD & FUNCTION
ISSN	2042-6496
	2023-01-03
卷号	14 期号:1 页码:427-444
DOI	10.1039/d2fo02812c
通讯作者	Li, Lili([email protected])
英文摘要	Alginate oligosaccharide is a kind of prebiotic with broad application prospects. However, little attention is paid to the recovery effect of alginate oligosaccharide on disordered intestinal microecology caused by azithromycin. Therefore, we evaluated the regulatory effect of alginate oligosaccharide and its compound on azithromycin-disturbed gut microbiota in mice via microbiome-metabolomics analysis. The gut microbiota analysis revealed that alginate oligosaccharide and its compound significantly increased the richness and diversity of the gut microbiota which were reduced by azithromycin, with an obvious enrichment of beneficial bacteria such as the Akkermansia genus and Bacteroides acidifaciens, and a remarkable decrease of pathogenic bacteria such as the Staphylococcus genus, which indicated its impact on the gut microbiota dysbiosis. Additionally, the effect of the alginate oligosaccharide compound on regulating the gut microbiota disorder is more significant than that of alginate oligosaccharide. The favorable effects of alginate oligosaccharide were confirmed by beneficial alterations in metabolic effector molecules, which indicated that alginate oligosaccharide and its compound improved metabolic homeostasis via the Bacteroides acidifaciens-fatty acid esters of hydroxy fatty acids (FAHFAs) axis and increasing the levels of the intermediate products of the tricarboxylic acid cycle (TCA cycle), such as citric acid, fumaric acid and alpha-ketoglutaric acid. Spearman correlation analysis showed that the contents of these three metabolites were also positively related to Bacteroides acidifaciens and Bacteroides sartorii populations, suggesting the potential regulatory role of the Bacteroides genus in energy balance through the TCA cycle. This study may provide an innovative dietary strategy for the regulation of intestinal microecological disorders caused by antibiotics, and reveal the prospect of alginate oligosaccharide as an intestinal microecological regulator.
资助机构	Science and Technology Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	ANTITUMOR IMMUNITY ; ANTIBIOTICS ; BACTERIA
研究领域[WOS]	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000897065000001
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32411
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Li, Lili
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Gastroenterol, Yantai, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai, Peoples R China 5.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Yan, Shuling,Zhu, Yanhong,Li, Lili,et al. Alginate oligosaccharide ameliorates azithromycin-induced gut microbiota disorder via Bacteroides acidifaciens-FAHFAs and Bacteroides-TCA cycle axes[J]. FOOD & FUNCTION,2023,14(1):427-444.
APA	Yan, Shuling.,Zhu, Yanhong.,Li, Lili.,Qin, Song.,Yuan, Jingyi.,...&Hu, Shanliang.(2023).Alginate oligosaccharide ameliorates azithromycin-induced gut microbiota disorder via Bacteroides acidifaciens-FAHFAs and Bacteroides-TCA cycle axes.FOOD & FUNCTION,14(1),427-444.
MLA	Yan, Shuling,et al."Alginate oligosaccharide ameliorates azithromycin-induced gut microbiota disorder via Bacteroides acidifaciens-FAHFAs and Bacteroides-TCA cycle axes".FOOD & FUNCTION 14.1(2023):427-444.