Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect

doi:10.1021/acssensors.2c02409

	Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect
	Mei, Rongchao 1,2; Wang, Yunqing2 ; Zhao, Xizhen 2; Shi, Shang 2; Wang, Xiaoyan 3; Zhou, Na 2; Shen, Dazhong 1; Kang, Qi 1; Chen, Lingxin2
发表期刊	ACS SENSORS
ISSN	2379-3694
	2023-01-13
页码	9
关键词	microneedles patch skin interstitial fluid surface-enhanced Raman scattering acute peritonitis
DOI	10.1021/acssensors.2c02409
通讯作者	Wang, Yunqing([email protected]) ; Kang, Qi([email protected]) ; Chen, Lingxin([email protected])
英文摘要	Skin interstitial fluid (ISF)-based microneedle (MN) sensing has recently exhibited wide promise for the minimally invasive and painless diagnosis of diseases. However, it is still a great challenge to diagnose more disease types due to the limited in situ sensing techniques and insufficient ISF biomarker sources. Herein, ISF is employed to pioneer the tracking of acute peritonitis progression via surface-enhanced Raman scattering (SERS) tags labeled MNs patch technique. Densely deposited core-satellite gold nanoparticles and 3-mercaptophenylboronic acid as a Raman reporter enable the developed MNs patch with high sensitivity and selectivity in the determination of H2O2, an indicator of peritonitis development. Importantly, the MNs patch not only reliably tracks the different states of peritonitis but also evaluates the efficacy of drugs in the treatment of peritonitis, as evidenced by the altered SERS signal consistent with plasma pro-inflammatory factor (TNF-alpha) and peritoneum pathological manifestations. Interestingly, the major source of H2O2 in ISF of acute peritonitis investigated may not be through conventional blood capillary filtration pathway. This work provides a new route and technique for the early diagnosis of acute peritonitis and the evaluation of drug therapy effects. The developed MNs patch is promising to serve as a universal sensing tool to greatly enrich the variety and prospect of ISF-based disease diagnosis.
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Taishan Scholars Program ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding
收录类别	SCI
语种	英语
关键词[WOS]	HYDROGEN-PEROXIDE ; CHEMILUMINESCENCE ; NANOPARTICLES ; BIOMARKERS ; GLUCOSE
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics
WOS记录号	WOS:000920315400001
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32087
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Wang, Yunqing; Kang, Qi; Chen, Lingxin
作者单位	1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,et al. Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect[J]. ACS SENSORS,2023:9.
APA	Mei, Rongchao.,Wang, Yunqing.,Zhao, Xizhen.,Shi, Shang.,Wang, Xiaoyan.,...&Chen, Lingxin.(2023).Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect.ACS SENSORS,9.
MLA	Mei, Rongchao,et al."Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect".ACS SENSORS (2023):9.