Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt

doi:10.3390/md20100646

	Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt
	Miao, Qin 1,2,3; Li, Qing1,2 ; Tan, Wenqiang1,2 ; Mi, Yingqi 1,2; Ma, Bing 1,2,3; Zhang, Jingjing 1,2; Guo, Zhanyong1,2
发表期刊	MARINE DRUGS
	2022-10-01
卷号	20 期号:10 页码:13
关键词	glucosamine-heparin salt glucosamine hydrochloride heparin sodium antioxidant activity anticoagulant activity
DOI	10.3390/md20100646
英文摘要	Excessive inorganic ions in vivo may lead to electrolyte disorders and induce damage to the human body. Therefore, preparation of enhanced bioactivity compounds, composed of activated organic cations and organic anions, is of great interest among researchers. In this work, glucosamine-heparin salt (GHS) was primarily synthesized with positively charged glucosamine hydrochloride (GAH) and negatively charged heparin sodium (Heps) by ion exchange method. Then, the detailed structural information of the GHS was characterized by FTIR, H-1 NMR spectroscopy and ICP-MS. In addition, its anticoagulant potency and antioxidant properties were evaluated, respectively. The results demonstrated that GHS salt achieved enhanced antioxidant activities, including 98.78% of O-2 center dot(-) radical scavenging activity, 91.23% of center dot OH radical scavenging rate and 66.49% of DPPH radical scavenging capacity at 1.6 mg/mL, severally. Meanwhile, anticoagulant potency (ATTP) of GHS strengthened from 153.10 +/- 17.14 to 180.03 +/- 6.02 at 0.75 mu mol/L. Thus, introducing cationic glucosamine residues into GHS could improve its anticoagulant activity. The findings suggest that GHS product with a small amount of inorganic ions can greatly abate the prime cost of antioxidants and anticoagulants, and has significant economic benefits and practical significance.
收录类别	SCI
语种	英语
关键词[WOS]	MOLECULAR-MECHANISMS ; CHROMATOGRAPHY
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000873168100001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31949
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Miao, Qin,Li, Qing,Tan, Wenqiang,et al. Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt[J]. MARINE DRUGS,2022,20(10):13.
APA	Miao, Qin.,Li, Qing.,Tan, Wenqiang.,Mi, Yingqi.,Ma, Bing.,...&Guo, Zhanyong.(2022).Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt.MARINE DRUGS,20(10),13.
MLA	Miao, Qin,et al."Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt".MARINE DRUGS 20.10(2022):13.