Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination

doi:10.1038/s41467-022-33448-w

	Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination
	Arabi, Maryam 1; Ostovan, Abbas 1; Wang, Yunqing1,2 ; Mei, Rongchao 1; Fu, Longwen1 ; Li, Jinhua1 ; Wang, Xiaoyan 1,3; Chen, Lingxin1,2,4
发表期刊	NATURE COMMUNICATIONS
	2022-09-30
卷号	13 期号:1 页码:14
DOI	10.1038/s41467-022-33448-w
通讯作者	Wang, Yunqing([email protected]) ; Chen, Lingxin([email protected])
英文摘要	Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an "inspector" recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted cavities, whereas the wrong cannot. Then a linear shape aminothiol molecule, as an inspector of the recognition status is introduced, which can only percolate through the vacant and nonspecifically occupied cavities, inducing the SERS signal to decrease. Accordingly, chirality information exclusively stems from good enantiomer specific binding, while nonspecific recognition of wrong enantiomer is curbed. The IRM benefits from sensitivity and versatility, enabling absolute discrimination of a wide variety of chiral molecules regardless of size, functional groups, polarities, optical activities, Raman scattering, and the number of chiral centers.
资助机构	Chinese Academy of Sciences President's International Fellowship Initiative ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences ; Taishan Scholar Project
收录类别	SCI
语种	英语
关键词[WOS]	POLYMERS ; PERSPECTIVES
研究领域[WOS]	Science & Technology - Other Topics
WOS记录号	WOS:000862415000025
引用统计	被引频次：175[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31752
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Wang, Yunqing; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Arabi, Maryam,Ostovan, Abbas,Wang, Yunqing,et al. Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination[J]. NATURE COMMUNICATIONS,2022,13(1):14.
APA	Arabi, Maryam.,Ostovan, Abbas.,Wang, Yunqing.,Mei, Rongchao.,Fu, Longwen.,...&Chen, Lingxin.(2022).Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.NATURE COMMUNICATIONS,13(1),14.
MLA	Arabi, Maryam,et al."Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination".NATURE COMMUNICATIONS 13.1(2022):14.