Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp

doi:10.1016/j.envpol.2022.120069

	Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp
	Zhu, Xiaopeng 1,2,3; Teng, Jia 1,2,3; Xu, Elvis Genbo 4; Zhao, Jianmin1,2 ; Shan, Encui 1,2,3; Sun, Chaofan 1,2,3; Wang, Qing1,2
发表期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
	2022-11-01
卷号	312 页码:12
关键词	Nanoplastics Titanium dioxide nanoparticle Litopenaeus vannamei Bioaccumulation Toxic effect Intestinal microbiota
DOI	10.1016/j.envpol.2022.120069
通讯作者	Wang, Qing([email protected])
英文摘要	Nanoplastic is recognized as an emerging environmental pollutant due to the anticipated ubiquitous distribution, increasing concentration in the ocean, and potential adverse health effects. While our understanding of the ecological impacts of nanoplastics is still limited, we benefit from relatively rich toxicological studies on other nanoparticles such as nano metal oxides. However, the similarity and difference in the toxicokinetic and tox-icodynamic aspects of plastic and metallic nanoparticles remain largely unknown. In this study, juvenile Pacific white shrimp Litopenaeus vannamei was exposed to two types of nanoparticles at environmentally relative low and high concentrations, i.e., 100 nm polystyrene nanoplastics (nano-PS) and titanium dioxide nanoparticles (nano-TiO2) via dietary exposure for 28 days. The systematic toxicological evaluation aimed to quantitatively compare the accumulation, excretion, and toxic effects of nano-PS and nano-TiO2. Our results demonstrated that both nanoparticles were ingested by L. vannamei with lower egestion of nano-TiO2 than nano-PS. Both nano -particles inhibited the growth of shrimps, damaged tissue structures of the intestine and hepatopancreas, dis-rupted expression of immune-related genes, and induced intestinal microbiota dysbiosis. Nano-PS exposure caused proliferative cells in the intestinal tissue, and the disturbance to the intestinal microbes was also more serious than that of nano-TiO2. The results indicated that the effect of nano-PS on the intestinal tissue of L. vannamei was more severe than that of nano-TiO2 with the same particle size. The study provides new theoretical basis of the similarity and differences of their toxicity, and highlights the current lack of knowledge on various aspects of absorption, distribution, metabolism, and excretion (ADME) pathways of nanoplastics.
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research and Development Project ; National Natural Science Fund of China ; Two-Hundred Talents Plan of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	GLUCAN BINDING-PROTEIN ; NANO-TITANIUM-DIOXIDE ; POLYSTYRENE MICROPLASTICS ; OXIDATIVE STRESS ; TIO2 NANOPARTICLES ; DAPHNIA-MAGNA ; TOXICITY ; MICROBIOTA ; ACCUMULATION ; NANOPLASTICS
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000860790500001
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31743
专题	海岸带生物学与生物资源利用重点实验室支撑部门_中国科学院牟平海岸带环境综合试验站海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Wang, Qing
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Southern Denmark, Dept Biol, DK-5230 Odense, Denmark
推荐引用方式 GB/T 7714	Zhu, Xiaopeng,Teng, Jia,Xu, Elvis Genbo,et al. Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp[J]. ENVIRONMENTAL POLLUTION,2022,312:12.
APA	Zhu, Xiaopeng.,Teng, Jia.,Xu, Elvis Genbo.,Zhao, Jianmin.,Shan, Encui.,...&Wang, Qing.(2022).Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp.ENVIRONMENTAL POLLUTION,312,12.
MLA	Zhu, Xiaopeng,et al."Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp".ENVIRONMENTAL POLLUTION 312(2022):12.