Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment

doi:10.1016/j.carres.2022.108597

	Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment
	Yang, Yunhui 1; Tan, Wenqiang2 ; Zhang, Jingjing 2; Guo, Zhanyong2 ; Jiang, Aili 1; Li, Qing2
发表期刊	CARBOHYDRATE RESEARCH
ISSN	0008-6215
	2022-08-01
卷号	518 页码:7
关键词	Inulin Coumarin Chemical modification Antioxidant activity
DOI	10.1016/j.carres.2022.108597
通讯作者	Jiang, Aili([email protected]) ; Li, Qing([email protected])
英文摘要	In this paper, a series of target derivatives were synthesized by introducing coumarin into inulin structure using three-step chemical modification, and their structures were characterized by FTIR, H-1 NMR, and C-13 NMR. At the same time, the antioxidant activities of inulin derivatives were determined, including DPPH-radical scavenging activity, superoxide-radical scavenging activity, PTIO-radical scavenging activity and reducing ability. The test results showed that the antioxidant activities of inulin derivatives containing coumarin were significantly increased. Especially, inulin derivatives showed excellent DPPH radical-scavenging ability (IC50 0.09-0.11 mg/mL). Meanwhile, the scavenging ability of PTIO-radical was increased by more than 80%, and the IC50 values were all between 0.23 and 0.26 mg/mL. At the concentration below 1 mg/mL, the scavenging rate of all inulin derivatives could even reach 100%. This study provides a feasible way to synthesize inulin derivatives with significant activity, which may be developed into new antioxidants in medicine and cosmetics.
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Guangdong Province
收录类别	SCI
语种	英语
关键词[WOS]	PREBIOTIC SUPPLEMENTATION ; CHITOSANS ; HEALTH ; ASSAY
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:000831011400004
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31609
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Jiang, Aili; Li, Qing
作者单位	1.Yantai Univ, Coll Life Sci, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yunhui,Tan, Wenqiang,Zhang, Jingjing,et al. Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment[J]. CARBOHYDRATE RESEARCH,2022,518:7.
APA	Yang, Yunhui,Tan, Wenqiang,Zhang, Jingjing,Guo, Zhanyong,Jiang, Aili,&Li, Qing.(2022).Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment.CARBOHYDRATE RESEARCH,518,7.
MLA	Yang, Yunhui,et al."Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment".CARBOHYDRATE RESEARCH 518(2022):7.