Investigation of interaction between MXene nanosheets and human plasma and protein corona composition

doi:10.1039/d1nr08548d

	Investigation of interaction between MXene nanosheets and human plasma and protein corona composition
	Wu, Xuri 1; Tan, Feng 1; Cheng, Shizhu 1; Chang, Yangyang 1; Wang, Xiaochun 2; Chen, Lingxin3
发表期刊	NANOSCALE
ISSN	2040-3364
	2022-02-09
页码	11
DOI	10.1039/d1nr08548d
通讯作者	Tan, Feng([email protected]) ; Chen, Lingxin([email protected])
英文摘要	The composition of protein corona affects the behavior and fate of nanoparticles in biological systems, which strongly relates to the intrinsic properties of nanoparticles and proteins. Here, three types of MXene Ti3C2Tx nanosheets are prepared by different etching methods, and certain physicochemical characteristics of the nanosheets before and after exposure to human plasma (HP) are characterized. The Ti3C2Tx nanosheets with protein coronas suffer more easily from aggregation than pristine Ti3C2Tx. The composition of protein coronas by LC-MS/MS-based label-free proteomic analysis reveals a high overlap of protein types and functions but a significant difference in relative protein abundance for the three Ti3C2Tx. Immunoglobulins and coagulation proteins are highly enriched while albumin is depleted in the coronas compared with their abundance in original HP. The random forest classification model predicts that the main driving forces for the adsorption of HP proteins on Ti3C2Tx are hydrogen bonding, steric hindrance, and hydrophobic interaction. This study provides insights into the colloidal stability of Ti3C2Tx nanosheets and their interaction with human plasma proteins.
资助机构	Natural Science Foundation of Liaoning Province of China ; Fundamental Research Funds for the Central Universities ; Dalian POCT laboratory ; National Natural Science Foundation of China
收录类别	SCI
语种	英语
关键词[WOS]	NANOPARTICLES DETERMINES ; SURFACE ; GOLD ; NANOMATERIALS ; EXFOLIATION ; ADSORPTION ; OXIDE ; SIZE
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:000757473500001
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31481
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Tan, Feng; Chen, Lingxin
作者单位	1.Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China 2.Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Shandong Prov Key Lab Biochem Engn, Qingdao 266042, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xuri,Tan, Feng,Cheng, Shizhu,et al. Investigation of interaction between MXene nanosheets and human plasma and protein corona composition[J]. NANOSCALE,2022:11.
APA	Wu, Xuri,Tan, Feng,Cheng, Shizhu,Chang, Yangyang,Wang, Xiaochun,&Chen, Lingxin.(2022).Investigation of interaction between MXene nanosheets and human plasma and protein corona composition.NANOSCALE,11.
MLA	Wu, Xuri,et al."Investigation of interaction between MXene nanosheets and human plasma and protein corona composition".NANOSCALE (2022):11.