Unveiling the occurrence, hosts and mobility potential of antibiotic resistance genes in the deep ocean

doi:10.1016/j.scitotenv.2021.151539

	Unveiling the occurrence, hosts and mobility potential of antibiotic resistance genes in the deep ocean
	Zhang, Haikun 1,2,3; Wang, Yibo 1; Liu, Pengyuan 1,4; Sun, Yanyu 1,4; Dong, Xiyang 5,6; Hu, Xiaoke1,2,3
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
	2022-04-10
卷号	816 页码:11
关键词	Antibiotic resistance genes Distribution Microbial host Mobility potential Deep-sea waters
DOI	10.1016/j.scitotenv.2021.151539
通讯作者	Dong, Xiyang([email protected]) ; Hu, Xiaoke([email protected])
英文摘要	As emerging microbial contaminants, antibiotic resistance genes (ARGs) are widely reported in the neritic zone. However, the profiles of ARGs in the deep ocean have not yet been fully resolved. In this study, the distribution, hosts, and mobility potential of ARGs at different water depths in the Western Pacific (WP) were investigated and compared to those in Bohai Sea (BH) waters using environmental parameter measurements, amplicon sequenc-ing, metagenomic assembly and binning approaches. Our results showed that the top eight most abundant known ARG types in WP and BH waters were multidrug (39.85%), peptide (14.98%), aminoglycoside (11.33%), macrolide-lincosamide-streptogramin (MLS, 4.06%), tetracycline (3.74%), beta-lactam (3.12%), fluoroquinolone (1.79%) and rifamycin (1.24%). The ARGs observed in mesopelagic and bathypelagic waters were abundant and diverse as those observed in neritic waters, indicating that deep-sea water could be another environmental reservoir for ARGs. For deep-sea ARGs, members from classes Gammaproteobacteria (70%) and Alphaproteobacteria (21.1%) were the most important potential hosts. In addition, mobile genetic element anal-ysis suggested that the ARG migration potential in dee sea water (> 1000 m) was relatively high. Overall, our findings expanded the understanding of ARGs in deep seawater and provided guidance for ARG pollution control and risk prediction. (C) 2021 Elsevier B.V. All rights reserved.
资助机构	National Key Research and Development Program ; National Natural Science Foundation of China ; Key Research Project of Frontier Science of Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; CSC Scholarship
收录类别	SCI
语种	英语
关键词[WOS]	BACTERIAL COMMUNITY COMPOSITION ; HEAVY-METALS ; SOIL ; ABUNDANCE ; FATE ; ARGS ; ENVIRONMENT ; SEQUENCES ; DRIVEN ; MANURE
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000764635400014
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31424
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Dong, Xiyang; Hu, Xiaoke
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Sun Yat Sen Univ, Sch Marine Sci, Zhuhai, Peoples R China 6.Guangdong Lab Zhuhai, Southern Marine Sci & Engn, Zhuhai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Haikun,Wang, Yibo,Liu, Pengyuan,et al. Unveiling the occurrence, hosts and mobility potential of antibiotic resistance genes in the deep ocean[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,816:11.
APA	Zhang, Haikun,Wang, Yibo,Liu, Pengyuan,Sun, Yanyu,Dong, Xiyang,&Hu, Xiaoke.(2022).Unveiling the occurrence, hosts and mobility potential of antibiotic resistance genes in the deep ocean.SCIENCE OF THE TOTAL ENVIRONMENT,816,11.
MLA	Zhang, Haikun,et al."Unveiling the occurrence, hosts and mobility potential of antibiotic resistance genes in the deep ocean".SCIENCE OF THE TOTAL ENVIRONMENT 816(2022):11.