Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application

doi:10.3390/molecules27092682

	Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application
	Tan, Wenqiang1,2 ; Lin, Conghao 3; Zhang, Jingjing 1,2; Li, Qing1,2 ; Guo, Zhanyong1,2
发表期刊	MOLECULES
	2022-05-01
卷号	27 期号:9 页码:13
关键词	hydroxypropyltrimethyl ammonium chitosan derivatives alpha-lipoic acid antioxidant activity
DOI	10.3390/molecules27092682
英文摘要	Hydroxypropyltrimethyl ammonium chloride chitosan (HACC) is one of the most important water-soluble chitosan derivatives; its derivatives have gained growing attention due to their potential biomedical applications. Here, hydroxypropyltrimethyl ammonium chitosan derivatives bearing thioctate (HACTs), with different degrees of substitution of thioctate, were prepared using HACC and alpha-lipoic acid as the reaction precursors, using an ion exchange method. The structural characteristics of the synthesized derivatives were confirmed by FTIR, H-1 NMR, and C-13 NMR spectroscopy. In addition, their antioxidant behaviors were also investigated in vitro by the assays of reducing power, and scavenging activities against hydroxyl radicals and DPPH radicals. The antioxidant assay indicated that HACTs displayed strong antioxidant activity compared with HACC, especially in terms of reducing power. Besides, the antioxidant activities of the prepared products were further enhanced with the increase in the test concentration and the degrees of substitution of thioctate. At the maximum test concentration of 1.60 mg/mL, the absorbance value at 700 nm of HACTs, under the test conditions, was 4.346 +/- 0.296, while the absorbance value of HACC was 0.041 +/- 0.007. The aforementioned results support the use of HACTs as antioxidant biomaterials in food and the biomedical field.
收录类别	SCI
语种	英语
关键词[WOS]	ALPHA-LIPOIC ACID ; CARBOXYMETHYL CHITOSAN ; ENHANCED ANTIOXIDANT ; ANTIFUNGAL ; POLYSACCHARIDES ; DESIGN
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:000796152900001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31075
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,et al. Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application[J]. MOLECULES,2022,27(9):13.
APA	Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,Li, Qing,&Guo, Zhanyong.(2022).Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application.MOLECULES,27(9),13.
MLA	Tan, Wenqiang,et al."Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application".MOLECULES 27.9(2022):13.