Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization

doi:10.1016/j.ijbiomac.2021.10.127

	Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization
	Hu, Dan 1; Zhang, Zhong 1; Yuan, Li 1; Li, Wenjun2 ; Guo, Yurong 1; Zhang, Runguang 1; Yang, Xingbin 1; Peng, Hailong 3
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2021-12-15
卷号	193 页码:127-136
关键词	Microgels Porous starch Phycocyanin Zebrafish Fluorescence imaging
DOI	10.1016/j.ijbiomac.2021.10.127
通讯作者	Zhang, Zhong([email protected]) ; Peng, Hailong([email protected])
英文摘要	Traditional bioactive substances are often limited in practical application due to their poor stability and low solubility. Therefore, it is imperative to develop biocompatible high loading microgel carriers. In this study, a novel type of casein-porous starch microgel was prepared under ultra-high-pressure homogenization, by using porous starch with the honeycomb three-dimensional network porous structure. Molecular interaction force analysis and thermodynamic analysis showed that electrostatic interaction played a major role in the formation of microgels. Circular dichroism and Fourier transform infrared spectroscopy showed that homogenization and pH were the main factors, which affected the formation and structural stability of microgels. Compared with casein-glutinous rice starch microgels, the encapsulation efficiency and loading capacity of phycocyanin in casein-porous starch microgels were increased by 77.27% and 135.10%, respectively. Thus, casein-porous starch microgels could not only achieve a sustained release effect, but also effectively transport phycocyanin to the gastrointestinal tract of zebrafish, while achieving good fluorescence imaging in vivo. Ultimately, the prepared casein-porous starch microgels could enrich the nanocarriers material, and contribute to the research of safe and effective fluorescent imaging materials.
资助机构	National Natural Science Foundation of China ; Postdoctoral Program of Shaanxi Province ; Fundamental Research Fund of the Central University
收录类别	SCI
语种	英语
关键词[WOS]	CONTROLLED-RELEASE ; NANOGELS ; DELIVERY ; NANOPARTICLES ; FABRICATION ; PARTICLES ; CARRIERS ; PROTEIN
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:000729556500003
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/30957
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院烟台海岸带研究所海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Zhang, Zhong; Peng, Hailong
作者单位	1.Shaanxi Normal Univ, Shaanxi Engn Lab Food Green Proc & Safety Control, Engn Res Ctr High Value Utilizat Western Fruit Re, Xian Key Lab Characterist Fruit Storage & Preserv, Xian 710062, Shaanxi, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China 3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Hu, Dan,Zhang, Zhong,Yuan, Li,et al. Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,193:127-136.
APA	Hu, Dan.,Zhang, Zhong.,Yuan, Li.,Li, Wenjun.,Guo, Yurong.,...&Peng, Hailong.(2021).Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,193,127-136.
MLA	Hu, Dan,et al."Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 193(2021):127-136.