Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis

doi:10.1016/j.ecoenv.2021.112904

	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
	Li, Fei1,2,4 ; Meng, Xiangjing 1,2,3; Wang, Xiaoqing1,2,3 ; Ji, Chenglong1,2,4 ; Wu, Huifeng1,2,4
发表期刊	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN	0147-6513
	2021-12-20
卷号	227 页码:8
关键词	Nanomaterials Graphene Organophosphorus ester (OPEs) Mytilus Joint effects Multi-omics
DOI	10.1016/j.ecoenv.2021.112904
通讯作者	Li, Fei([email protected]) ; Wu, Huifeng([email protected])
英文摘要	Both immune regulation and endocrine systems are great challenges to marine organisms, and effective protocols for determining these adverse outcome pathways are limited, especially in vivo. The increasing usage of graphene nanomaterials can lead to the frequent exposure to marine organisms. Triphenyl phosphate (TPP), an organophosphate flame retardant, is frequently detected in natural environments. In this study, the combined toxic effects of co-exposure to graphene and TPP was investigated in Mytilus galloprovincialis using computational toxicology and multi-omics technology. Noticeably, graphene could disturb the membrane stability and increase the tissue accumulation of TPP. The adsorption behavior of TPP on graphene could inhibit the surface activity of graphene. In the digestive gland, transcriptomics analysis revealed the down-regulated genes in graphene + TPP treatment, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), sorbitol dehydrogenase (SORD), glutathione s-transferase mu 3 (GSTM3) and 4-aminobutyrate aminotransferase (ABAT), were mainly associated with oxidative stress and energy metabolism. Moreover, metabolic responses indicated that graphene + TPP could cause disturbances in energy metabolism and osmotic regulation marked by differentially altered ATP, glucose and taurine in mussels. These data underline the need for further knowledge on the potential interactions of nanomaterials with existing contaminants in marine organisms.
资助机构	Yantai Science and Technology Development Plan ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS
收录类别	SCI
语种	英语
关键词[WOS]	WALLED CARBON NANOTUBES ; FLAME RETARDANTS ; RELEVANT CONCENTRATIONS ; NANOPARTICLES ; OXIDE ; METABOLOMICS ; RESPONSES ; TOXICITY ; PERTURBATIONS ; PLASTICIZERS
研究领域[WOS]	Environmental Sciences & Ecology ; Toxicology
WOS记录号	WOS:000708544100006
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/30822
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Li, Fei; Wu, Huifeng
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Fei,Meng, Xiangjing,Wang, Xiaoqing,et al. Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,227:8.
APA	Li, Fei,Meng, Xiangjing,Wang, Xiaoqing,Ji, Chenglong,&Wu, Huifeng.(2021).Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,227,8.
MLA	Li, Fei,et al."Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 227(2021):8.