Janthinoid A, an unprecedented tri-nor-meroterpenoid with highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold, produced by the endophyte of Penicillium janthinellum TE-43

doi:10.1039/d1qo01066b

	Janthinoid A, an unprecedented tri-nor-meroterpenoid with highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold, produced by the endophyte of Penicillium janthinellum TE-43
	Li, Xiao-Dong 1; Su, Jun-Cheng 2; Jiang, Bao-Zhen 3; Li, Ye-Ling 4,5; Guo, Yuan-Qiang 4,5; Zhang, Peng 6
发表期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
	2021-09-20
页码	7
DOI	10.1039/d1qo01066b
通讯作者	Li, Xiao-Dong() ; Guo, Yuan-Qiang() ; Zhang, Peng()
英文摘要	Janthinoid A (1), an unprecedented C-22 meroterpenoid featuring a highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold incorporating eight continuous quaternary carbons, along with its biosynthetic-related C-25 analogue andrastone I (2), were isolated from the endophytic fungus Penicillium janthinellum TE-43. Their structures were unambiguously established by comprehensive analyses of spectroscopic data, quantum chemical calculations, and X-ray diffraction. The tri-nor-meroterpenoid skeleton of 1 was produced by a unique biosynthetic pathway, involving the ring cleavage and continuous carbon degradations of the aromatic polyketide precursor, which is distinct from the commonly-observed meroterpenoids both structurally and biogenetically, representing a new type of meroterpenoid. Both compounds showed significant in vivo anti-tumor activities against NSCLC cells A549.
资助机构	National Natural Science Foundation of China ; Central Public-Interest Scientific Institution Basal Research Fund
收录类别	SCI
语种	英语
关键词[WOS]	ALPHA-KETOLS ; ZEBRAFISH ; METASTASIS ; CLEAVAGE ; CANCER
研究领域[WOS]	Chemistry
WOS记录号	WOS:000704422200001
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/30763
专题	中国科学院烟台海岸带研究所知识产出
通讯作者	Li, Xiao-Dong; Guo, Yuan-Qiang; Zhang, Peng
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai 200025, Peoples R China 3.Shandong Agr Univ, Coll Plant Protect, Tai An 271018, Shandong, Peoples R China 4.Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 5.Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300350, Peoples R China 6.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Dong,Su, Jun-Cheng,Jiang, Bao-Zhen,et al. Janthinoid A, an unprecedented tri-nor-meroterpenoid with highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold, produced by the endophyte of Penicillium janthinellum TE-43[J]. ORGANIC CHEMISTRY FRONTIERS,2021:7.
APA	Li, Xiao-Dong,Su, Jun-Cheng,Jiang, Bao-Zhen,Li, Ye-Ling,Guo, Yuan-Qiang,&Zhang, Peng.(2021).Janthinoid A, an unprecedented tri-nor-meroterpenoid with highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold, produced by the endophyte of Penicillium janthinellum TE-43.ORGANIC CHEMISTRY FRONTIERS,7.
MLA	Li, Xiao-Dong,et al."Janthinoid A, an unprecedented tri-nor-meroterpenoid with highly modified bridged 4a,1-(epoxymethano)phenanthrene scaffold, produced by the endophyte of Penicillium janthinellum TE-43".ORGANIC CHEMISTRY FRONTIERS (2021):7.