| Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models | |
Wang, Yude1,2,3; Wei, Yinghui1,2; He, Na4; Zhang, Liangwei3 ; You, Jinmao5; Chen, Lingxin3,5; Lv, Changjun1,2
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| 发表期刊 | JOURNAL OF MATERIALS CHEMISTRY B
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| ISSN | 2050-750X |
| 2021-07-10 | |
| 页码 | 8 |
| DOI | 10.1039/d1tb01307f |
| 通讯作者 | Zhang, Liangwei([email protected]) ; Chen, Lingxin([email protected]) ; Lv, Changjun([email protected]) |
| 英文摘要 | Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal interstitial lung disease due to various challenges in diagnosis and treatment. Due to its complicated pathogenesis and difficulty in early diagnosis, there is no effective cure. Cyclooxygenase-2 (COX-2) is inextricably associated with pulmonary fibrosis. The abnormal level of COX-2 leads to extremely exacerbated pulmonary fibrosis. Therefore, we reported a near-infrared fluorescent probe Cy-COX to detect the fluctuation of COX-2 levels during pulmonary fibrosis and explain its important protective effect. The probe Cy-COX showed a significant enhancement of fluorescence signal to COX-2 with excellent selectivity and sensitivity. In order to clarify the relationship between COX-2 and pulmonary fibrosis, we used the probe Cy-COX to detect COX-2 fluctuation in organisms with pulmonary fibrosis. The results showed that the COX-2 level increased in the early stage and decreased in the late stage with the aggravation of pulmonary fibrosis. Furthermore, up-regulation of COX-2 levels can effectively alleviate the severity of pulmonary fibrosis. Therefore, Cy-COX is a fast and convenient imaging tool with great potential to predict the early stage of pulmonary fibrosis and evaluate the therapeutic effects. |
| 资助机构 | National Natural Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | INTERSTITIAL LUNG-DISEASE ; CANCER ; COX-2 ; FIBROBLASTS ; PATHOGENESIS ; INFLAMMATION ; EXPRESSION |
| 研究领域[WOS] | Materials Science |
| WOS记录号 | WOS:000678242600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/29549 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Zhang, Liangwei; Chen, Lingxin; Lv, Changjun |
| 作者单位 | 1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China 2.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 4.Shandong Univ, Cheelo Coll Med, Qilu Hosp, Rehabil Ctr, Jinan 250100, Peoples R China 5.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yude,Wei, Yinghui,He, Na,et al. Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021:8. |
| APA | Wang, Yude.,Wei, Yinghui.,He, Na.,Zhang, Liangwei.,You, Jinmao.,...&Lv, Changjun.(2021).Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models.JOURNAL OF MATERIALS CHEMISTRY B,8. |
| MLA | Wang, Yude,et al."Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models".JOURNAL OF MATERIALS CHEMISTRY B (2021):8. |
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