| Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis | |
Wang, Shuang1; Ji, Chenglong1,2,3 ; Li, Fei1,3; Zhan, Junfei1,4; Sun, Tao1,4; Tang, Jianhui1,3; Wu, Huifeng1,2,3
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| 发表期刊 | JOURNAL OF HAZARDOUS MATERIALS
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| ISSN | 0304-3894 |
| 2021-08-15 | |
| 卷号 | 416页码:9 |
| 关键词 | Brominated flame retardants Marine invertebrates Endocrine disruptor Steroids sulfonation |
| DOI | 10.1016/j.jhazmat.2021.126228 |
| 通讯作者 | Ji, Chenglong([email protected]) ; Wu, Huifeng([email protected]) |
| 英文摘要 | Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. However, limited attention of TBBPA's endocrine-disrupting effects has been paid on marine invertebrates. In this work, the reproductive endocrine-disrupting effects of TBBPA were evaluated by observing the gametes development, quantifying the gender-specific gene expression, and determining vertebrate sex hormones in mussels Mytilus galloprovincialis treated with TBBPA for 30 days. Additionally, transcriptomic profiling and enzymes activities were conducted to investigate the potential mechanisms of reproductive endocrine-disrupting effects. We found that promotion of gametogenesis and alterations of vertebrate sex hormones occurred in TBBPA-treated mussels of both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) were up-regulated at transcript level as a result of TBBPA treatments, suggesting that TBBPA disrupted the steroidogenesis in mussels through promoting steroids sulfo-nation and hydrolysis of sulfate steroids. The induction of SULTs for TBBPA biotransformation might be responsible for the dysregulation of steroidogenesis and steroids metabolism. Overall, these findings provide a new insight into assessing impact of TBBPA as well as TBBPA biomonitoring in marine environment. |
| 资助机构 | National Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS ; Yantai Science and Technology Development Plan |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | GENDER-SPECIFIC RESPONSES ; SCALLOP CHLAMYS-FARRERI ; TESTOSTERONE CONCENTRATIONS ; BISPHENOL-A ; TBBPA ; ESTRADIOL-17-BETA ; SEX ; GAMETOGENESIS ; GLUCURONIDE ; SULFATASE |
| 研究领域[WOS] | Engineering ; Environmental Sciences & Ecology |
| WOS记录号 | WOS:000664769200005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/29459 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Ji, Chenglong; Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Processes, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai Inst Coastal Zone Res,YICCAS, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 26071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shuang,Ji, Chenglong,Li, Fei,et al. Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416:9. |
| APA | Wang, Shuang.,Ji, Chenglong.,Li, Fei.,Zhan, Junfei.,Sun, Tao.,...&Wu, Huifeng.(2021).Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,416,9. |
| MLA | Wang, Shuang,et al."Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 416(2021):9. |
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