| Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities | |
Mi, Yingqi1,2,3; Zhang, Jingjing1,2; Han, Xiangru4; Tan, Wenqiang1,2 ; Miao, Qin1,2,3; Cui, Jingmin1,2,3; Li, Qing1,2; Guo, Zhanyong1,2,3
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2021-06-30 | |
| 卷号 | 181页码:572-581 |
| 关键词 | Carboxymethyl inulin Antioxidant Heterocyclic moieties |
| DOI | 10.1016/j.ijbiomac.2021.03.109 |
| 通讯作者 | Guo, Zhanyong([email protected]) |
| 英文摘要 | A series of novel inulin derivatives were designed and synthesized by the introduction of amino heterocyclic moieties onto carboxymethyl inulin with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hyd roxysucci ni mide. The target products were prepared via three - step chemical synthesis, and structures were identified by FTIR and H-1 NMR spectroscopy. Antioxidant activities of inulin derivatives including DPPH - radical scavenging assay, superoxide - radical scavenging assay, hydroxyl - radical scavenging assay, and reducing power were estimated. Meanwhile, their antifungal activities, including Colletotrichum lagenarium and Bottytis cinerea, were also explored by hyphal measurement. In particular, inulin derivatives bearing heterocyclic moieties exhibited a remarkable improvement over inulin on antioxidant and antifungal activities, and their bioactivities decreased roughly in the order of 2ATCMI > 4APCMI > 3APCMI > 2APCMI > 3ATCMI > CMI > inulin. Furthermore, the cytotoxicities of inulin derivatives against L929 cells were evaluated by CCK-8 in vitro, and all samples showed weak cytotoxicities. In a nutshell, the paper provides a practical approach to synthesize novel inulin derivatives with dramatically enhanced bioactivity and good biocompatibility. The product described in paper might serve as a new leading structure for further design of antioxidants or antifungal agents in biomedicine, cosmetics, and other fields. (C) 2021 Elsevier B.V. All rights reserved. |
| 资助机构 | National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | IN-VITRO ; DERIVATIVES ; PREDICTION ; CHITOSANS |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS记录号 | WOS:000656891400007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/29383 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yantai Univ, Coll Environm & Mat Engn, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mi, Yingqi,Zhang, Jingjing,Han, Xiangru,et al. Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,181:572-581. |
| APA | Mi, Yingqi.,Zhang, Jingjing.,Han, Xiangru.,Tan, Wenqiang.,Miao, Qin.,...&Guo, Zhanyong.(2021).Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,181,572-581. |
| MLA | Mi, Yingqi,et al."Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 181(2021):572-581. |
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