| Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models | |
He, Na1; Wang, Yude2; Huang, Yan2,3; Chen, Lingxin3 ; Wang, Xiaoyan2,3; Lv, Changjun2; Yue, Shouwei1
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| 发表期刊 | JOURNAL OF MATERIALS CHEMISTRY B
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| ISSN | 2050-750X |
| 2020-11-21 | |
| 卷号 | 8期号:43页码:9899-9905 |
| DOI | 10.1039/d0tb01969k |
| 通讯作者 | Chen, Lingxin([email protected]) ; Lv, Changjun([email protected]) ; Yue, Shouwei([email protected]) |
| 英文摘要 | Acute lung injury (ALI) is a diffuse inflammatory pulmonary damage caused by excessive ROS that break the coordination of normal physiological structures and functions. Hypochlorous acid (HOCl), one kind of ROS, is a hopeful biological marker for inflammation-related diseases. Therefore, the excessive generation of HOCl might be a significant reason for oxidative injury in ALI. Herein, we developed a fluorescent probe, namely BCy-HOCl, for quantitatively monitoring and visualizing HOCl in living cells and in vivo. The probe BCy-HOCl displayed a significant fluorescence signal enhancement towards HOCl with excellent selectivity and sensitivity. The variation of HOCl in the ALI cell model and ALI mouse model was evaluated with BCy-HOCl to clarify the relationship between ALI and HOCl. Our results verified that the HOCl levels conspicuously increased with the severity of the ALI. Thus, HOCl is likely to play a crucial part in the process of ALI, which will probably provide a new strategy for its treatment. |
| 资助机构 | National Nature Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | RESPIRATORY-DISTRESS-SYNDROME ; IMAGING BASAL ; LIVE-CELL ; MITOCHONDRIA ; HCLO ; LYSOSOME |
| 研究领域[WOS] | Materials Science |
| WOS记录号 | WOS:000588549200006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28336 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Chen, Lingxin; Lv, Changjun; Yue, Shouwei |
| 作者单位 | 1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China 2.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Na,Wang, Yude,Huang, Yan,et al. Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(43):9899-9905. |
| APA | He, Na.,Wang, Yude.,Huang, Yan.,Chen, Lingxin.,Wang, Xiaoyan.,...&Yue, Shouwei.(2020).Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models.JOURNAL OF MATERIALS CHEMISTRY B,8(43),9899-9905. |
| MLA | He, Na,et al."Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models".JOURNAL OF MATERIALS CHEMISTRY B 8.43(2020):9899-9905. |
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| Detection of hypochl（3443KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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