| Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus | |
Zhang, Hongxia1,2,3,4; Wang, Qing3,5 ; Zhao, Jianmin3,5; Liu, Shilin1,2,3,4; Zhang, Libin1,2,3,4,8; Zhao, Ye6; Yang, Hongsheng1,2,3,4,7; Sun, Lina1,2,3,4
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| 发表期刊 | GENOMICS
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| ISSN | 0888-7543 |
| 2020-11-01 | |
| 卷号 | 112期号:6页码:5012-5020 |
| 关键词 | Apostichopus japonicus Intestine regeneration Intestinal microbiota Quantitative microbiome Regeneration rate |
| DOI | 10.1016/j.ygeno.2020.09.017 |
| 通讯作者 | Sun, Lina([email protected]) |
| 英文摘要 | The intestinal microbiota may play important roles in regenerating intestine of the sea cucumber Apostichopus japonicus, the underlying mechanism remains unclear. In the present study, a germ-free sea cucumber model was developed, and the intestinal microbial differentiation of faster and slower regenerating A. japonicus individuals during intestine regeneration was analyzed. The results revealed that depletion of the intestinal microbiota resulted in elevated abundance of the potential key players Flavobacteriaceae and Rhodobacteraceae during intestine regeneration and thus promoted the intestine regeneration rate of A. japonicus. Metagenomic analysis revealed that the increased abundance of Flavobacteriaceae elevated the enrichment of genes associated with carbohydrate utilization, whereas the abundant Rhodobacteraceae-enriched genes were associated with polyhydroxybutyrate production. We identified microbiota abundance as a key driver of microbial community alterations, especially beneficial microbiota members, in the developing intestine of A. japonicus. This study provides new insights into the mechanism of host-microbiota interactions related to organ regeneration. |
| 资助机构 | National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Youth Talent Support Program of the Laboratory for Marine Ecology and Environmental Science ; Pilot National Laboratory for Marine Science and Technology (Qingdao) ; Taishan Scholars Program (Distinguished Taishan Scholars), TwoHundred Talents Plan of Yantai ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | BACTERIAL DIVERSITY ; GUT ; EXPRESSION ; GROWTH ; FLAVOBACTERIACEAE ; IDENTIFICATION ; ALIGNMENT ; PROTEIN ; GENES |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS记录号 | WOS:000600731500010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27544 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, CAS Res & Dev Ctr Efficient Utilizat Coastal Bior, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 6.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China 7.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China 8.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hongxia,Wang, Qing,Zhao, Jianmin,et al. Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus[J]. GENOMICS,2020,112(6):5012-5020. |
| APA | Zhang, Hongxia.,Wang, Qing.,Zhao, Jianmin.,Liu, Shilin.,Zhang, Libin.,...&Sun, Lina.(2020).Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus.GENOMICS,112(6),5012-5020. |
| MLA | Zhang, Hongxia,et al."Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus".GENOMICS 112.6(2020):5012-5020. |
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