| Phenolic-containing chitosan quaternary ammonium derivatives and their significantly enhanced antioxidant and antitumor properties | |
Li, Qing1,2 ; Li, Qiang3; Tan, Wenqiang1,2; Zhang, Jingjing1,2; Guo, Zhanyong1
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| 发表期刊 | CARBOHYDRATE RESEARCH
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| ISSN | 0008-6215 |
| 2020-12-01 | |
| 卷号 | 498页码:8 |
| 关键词 | Chitosan Antioxidant activity Phenolic |
| DOI | 10.1016/j.carres.2020.108169 |
| 通讯作者 | Guo, Zhanyong([email protected]) |
| 英文摘要 | A class of phenolic-chitosan quaternary ammonium derivatives have been designed and synthesized. Three chitosan derivatives possess effective structure of hydroxycinnamic acid have been obtained through chemical modification to get chitosan derivatives owning high antioxidant activity and antitumor activity. In this study, the scavenging ability of DPPH, hydroxyl (center dot OH), and superoxide (O2 center dot-) free radical and reducing power have been tested to evaluate the antioxidant activity of the synthesized chitosan derivatives. Base on the value of IC50, the chitosan derivatives have the best inhibitory property of 0.019 mg/mL (DPPH), 0.016 mg/mL (center dot OH), and 0.008 (O-2 center dot-), respectively; and the chitosan derivatives with conjugate structure of ferulic acid and sinapic acid (4b and 4c) show promising antitumor activity toward A549 cells with the IC50 of 0.046 and 0.052 mg/mL. These data indicate that the chitosan derivatives with phenolic group give much stronger antioxidant activity and antitumor activity. On the other hand, the synthesized chitosan derivatives show no cytotoxicity for L929 cells at the testing concentrations. These results demonstrate that the introduction of phenol group improves the antioxidant activity of chitosan obviously, and the antioxidant or free radical scavenger based on nature polymers and phenol shows potentials application. |
| 资助机构 | Key Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong Province ; National Key Research and Development Project |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | FERULIC ACID ; INULIN DERIVATIVES ; AGENTS ; FLAVONOIDS ; MECHANISM ; CELLS |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000599717100008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27535 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qing,Li, Qiang,Tan, Wenqiang,et al. Phenolic-containing chitosan quaternary ammonium derivatives and their significantly enhanced antioxidant and antitumor properties[J]. CARBOHYDRATE RESEARCH,2020,498:8. |
| APA | Li, Qing,Li, Qiang,Tan, Wenqiang,Zhang, Jingjing,&Guo, Zhanyong.(2020).Phenolic-containing chitosan quaternary ammonium derivatives and their significantly enhanced antioxidant and antitumor properties.CARBOHYDRATE RESEARCH,498,8. |
| MLA | Li, Qing,et al."Phenolic-containing chitosan quaternary ammonium derivatives and their significantly enhanced antioxidant and antitumor properties".CARBOHYDRATE RESEARCH 498(2020):8. |
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| Phenolic-containing （731KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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