| Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment | |
Li, Qing1,2 ; Mi, Yingqi1,3; Tan, Wenqiang1,2; Guo, Zhanyong1,2
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2020-12-01 | |
| 卷号 | 164页码:4279-4288 |
| 关键词 | Chitosan Free radical-scavenging Chemical modification |
| DOI | 10.1016/j.ijbiomac.2020.08.250 |
| 通讯作者 | Guo, Zhanyong([email protected]) |
| 英文摘要 | Chitosan is an abundant and renewable polysaccharide, and chemical modification can be used to enhance the biological properties of chitosan. In this study, monophenol and ortho-diphenol were introduced to chitosan through chemical modification to get chitosan derivatives owned high antioxidant activity. Their free radical-scavenging activity against three free radicals and reduction ability was tested. Based on the four antioxidant assay, the antioxidant ability of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of inhibition of DPPH, hydroxyl ((OH)-O-center dot), and superoxide (O2 center dot-) radical-scavenging was 41-172, 10-89, and 14-38 mu g/mL, respectively. Meanwhile, ortho-diphenol was more efficient group than monophenol on the improvement of antioxidant ability of chitosan derivatives. The possible free radical-scavenging mechanism, including the number of the hydroxyl groups and the presence ortho-dihydroxy substitution for the antioxidant ability were discussed. In vitro studies demonstrated that the constructed chitosan derivatives have good biocompatibility, and good antioxidant capacity to reduce oxidative stress. Functionalization of chitosan with phenolic group allows the possible applications on the therapy of oxidative-related diseases. (C) 2020 Elsevier B.V. All rights reserved. |
| 资助机构 | Key Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong ; National Key Research & Development Program of China |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ANTIOXIDANT ACTIVITY ; INULIN DERIVATIVES ; OXIDATIVE STRESS ; FLAVONOIDS ; POLYPHENOLS ; MECHANISMS ; AGENTS ; DPPH ; DFT |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS记录号 | WOS:000588093700407 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27514 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qing,Mi, Yingqi,Tan, Wenqiang,et al. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,164:4279-4288. |
| APA | Li, Qing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2020).Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,164,4279-4288. |
| MLA | Li, Qing,et al."Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164(2020):4279-4288. |
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