| The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia | |
Song, Hao1,2,3,4; Guo, Ximing5; Sun, Lina1,2,3,4,6; Wang, Qianghui8; Han, Fengming8; Wang, Haiyan1,2,3,6; Wray, Gregory A.9; Davidson, Phillip9; Wang, Qing6,7 ; Hu, Zhi1,2,6; Zhou, Cong1,2,6; Yu, Zhenglin1,2,3,4; Yang, Meijie1,2,6; Feng, Jie1,2,3,4; Shi, Pu1,2,6; Zhou, Yi1,2,3,4,6; Zhang, Libin1,2,3,4,6; Zhang, Tao1,2,3,4,6
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| 发表期刊 | BMC BIOLOGY
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| 2021-01-25 | |
| 卷号 | 19期号:1页码:20 |
| 关键词 | IAP gene family Molecular evolution Mollusca Gene duplication Divergence |
| DOI | 10.1186/s12915-020-00943-9 |
| 通讯作者 | Zhang, Tao([email protected]) |
| 英文摘要 | Background Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are essential for development, oncogenesis, and immune and stress responses. However, available knowledge regarding IAP is largely biased toward humans and model species, while the distribution, function, and evolutionary novelties of this gene family remain poorly understood in many taxa, including Mollusca, the second most speciose phylum of Metazoa. Results Here, we present a chromosome-level genome assembly of an economically significant bivalve, the hard clam Mercenaria mercenaria, which reveals an unexpected and dramatic expansion of the IAP gene family to 159 members, the largest IAP gene repertoire observed in any metazoan. Comparative genome analysis reveals that this massive expansion is characteristic of bivalves more generally. Reconstruction of the evolutionary history of molluscan IAP genes indicates that most originated in early metazoans and greatly expanded in Bivalvia through both lineage-specific tandem duplication and retroposition, with 37.1% of hard clam IAPs located on a single chromosome. The expanded IAPs have been subjected to frequent domain shuffling, which has in turn shaped their architectural diversity. Further, we observed that extant IAPs exhibit dynamic and orchestrated expression patterns among tissues and in response to different environmental stressors. Conclusions Our results suggest that sophisticated regulation of apoptosis enabled by the massive expansion and diversification of IAPs has been crucial for the evolutionary success of hard clam and other molluscan lineages, allowing them to cope with local environmental stresses. This study broadens our understanding of IAP proteins and expression diversity and provides novel resources for studying molluscan biology and IAP function and evolution. |
| 资助机构 | National Key R&D Program of China ; earmarked fund for the Modern Agro-industry Technology Research System ; Major Applied Technology Innovation Project in Agriculture of Shandong Province ; Supporting Program of Science and Technology Service Network Initiative in Fujian Province ; Industry Leading Talents Project of Taishan Scholars ; Double Hundred Blue Industry Leader Team of Yantai |
| 收录类别 | SCI |
| 语种 | 英语 |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| WOS记录号 | WOS:000613072400002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27466 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Zhang, Tao |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ USA 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China 8.Novogene Bioinformat Inst, Beijing 100029, Peoples R China 9.Duke Univ, 130 Sci Dr, Durham, NC 27708 USA |
| 推荐引用方式 GB/T 7714 | Song, Hao,Guo, Ximing,Sun, Lina,et al. The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia[J]. BMC BIOLOGY,2021,19(1):20. |
| APA | Song, Hao.,Guo, Ximing.,Sun, Lina.,Wang, Qianghui.,Han, Fengming.,...&Zhang, Tao.(2021).The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia.BMC BIOLOGY,19(1),20. |
| MLA | Song, Hao,et al."The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia".BMC BIOLOGY 19.1(2021):20. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The hard clam genome（7615KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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