| Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging | |
He, Na1; Yu, Lei2; Xu, Minghua3; Huang, Yan4,5; Wang, Xiaoyan4,5; Chen, Lingxin4,5,6 ; Yue, Shouwei1
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| 发表期刊 | JOURNAL OF MATERIALS CHEMISTRY B
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| ISSN | 2050-750X |
| 2021-03-21 | |
| 卷号 | 9期号:11页码:2623-2630 |
| DOI | 10.1039/d0tb02833a |
| 通讯作者 | Chen, Lingxin([email protected]) ; Yue, Shouwei([email protected]) |
| 英文摘要 | Dietary restriction (DR), as a natural intervention, not only benefits the neuroendocrine system, but also has an antiaging action. Acetylcholinesterase (AChE) is one of the most important bioactive substances and plays a major part in choline changes in the aging process. Thus, we aim to evaluate the effect of DR on AChE in the brains of aging animals. In this study, we synthesize a NIR fluorescent probe BD-AChE for the real-time and in situ monitoring of AChE level changes in living cells and living mice, notably in brains. In situ visualization with BD-AChE verified a decrease in the AchE level in the brains of mice aging models. Evidently, the prepared probe has the excellent capability of measuring AChE variation in the brains of aging mice with DR via NIR fluorescence bioimaging, indicating that long-term DR can effectively affect AChE levels in the brain. The attenuation of AChE level in the brain of aging mice after DR could be helpful in infering the advantageous impact of DR on age-related neurodegenerative disease, as a better treatment alternative in the future. |
| 资助机构 | National Nature Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization ; Weifang Science and Technology Development Project |
| 收录类别 | SCI |
| 语种 | 英语 |
| 研究领域[WOS] | Materials Science |
| WOS记录号 | WOS:000632213400003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27245 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Chen, Lingxin; Yue, Shouwei |
| 作者单位 | 1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China 2.Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Peoples R China 3.Yantai Cent Blood Stn, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 6.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Na,Yu, Lei,Xu, Minghua,et al. Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(11):2623-2630. |
| APA | He, Na.,Yu, Lei.,Xu, Minghua.,Huang, Yan.,Wang, Xiaoyan.,...&Yue, Shouwei.(2021).Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging.JOURNAL OF MATERIALS CHEMISTRY B,9(11),2623-2630. |
| MLA | He, Na,et al."Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging".JOURNAL OF MATERIALS CHEMISTRY B 9.11(2021):2623-2630. |
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