| Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction | |
Tan, Wenqiang1,2 ; Zhang, Jingjing1,2; Mi, Yingqi1,2,3; Dong, Fang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2020-12-15 | |
| 卷号 | 165页码:1765-1772 |
| 关键词 | Chitosan Azide-alkyne click reaction Triphenylphosphonium Antifungal activity |
| DOI | 10.1016/j.ijbiomac.2020.10.019 |
| 通讯作者 | Guo, Zhanyong([email protected]) |
| 英文摘要 | As one of the most promising biopolymers for a variety of potential applications, chitosan has attractedmuch attention because of its unique biological, chemical, and physical properties. The functionalization of chitosan has been adopted to synthesize novel chitosan derivatives with improved water-solubility and excellent biological activities. In this paper, chitosanwas functionalized with a triphenylphosphoniumgroup by means of the copper (I) catalyzed azide-alkyne "click" reaction and has been investigated as potential polymer for agricultural antifungal biomaterial. The influence of chemical modification on the structural characteristics and water-solubility of chitosanwas investigated by FTIR spectroscopy, H-1 NMRspectroscopy, elemental analysis, and UV-vis spectrum. Furthermore, the antifungal property of target chitosan derivative against four plant threatening fungal pathogens was evaluated and in vitro investigation demonstrated that triphenylphosphoniumsalt incorporated chitosan backbone had excellent antifungal property compared with chitosan and intermediate chitosan derivative. Notably, target chitosan derivative displayed relatively strongest antifungal effect with over 80% inhibitory index against Botrytis cinerea at 1.0 mg/mL. The results of a detailed antifungal study indicated that cationic chitosan derivative bearing 1,2,3-triazole and triphenylphosphonium moieties provided a promising platform for preparation of novel cationic antifungal biomaterials in the field of agriculture. (C) 2020 Elsevier B.V. All rights reserved. |
| 资助机构 | Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ANTIMICROBIAL ACTIVITY ; QUATERNARY AMMONIUM ; PHOSPHONIUM ; ANTIOXIDANT ; CHEMISTRY |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS记录号 | WOS:000600773500016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/26156 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,et al. Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,165:1765-1772. |
| APA | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,Dong, Fang,Li, Qing,&Guo, Zhanyong.(2020).Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,165,1765-1772. |
| MLA | Tan, Wenqiang,et al."Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 165(2020):1765-1772. |
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| Enhanced antifungal （1267KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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