海岸带生物学与生物资源保护实验室知识库

(1) 中国科学院烟台海岸带研究所海岸带生物学与生物资源利用重点实验室

Sugar transporter proteins are located in the cell membrane and are a group of important transmembrane proteins.Sugar transporter proteins transport carbohydrate from extracellular to intracellular for the use of cells.Sugar transporter proteins,as sugar sensors,play an important role in eukaryotic microalgae,breast-feeding animals and higher plants.In this study,comparative genomics analyses were applied to study sugar transporter proteins and to explore their distribution,classification,phylogeny,evolution and structure in eukaryotic microalgae.Twenty-eight eukaryotic microalgae genomes were examined for putative genes of sugar transporter proteins and 70 putative sugar transporter protein sequences were found,which were 9 types of HUP1,39 types of HUP2 and 22 types of HUP3.Sugar transporter genes of eukaryotic microalgae were origin of bacterium.In this study,a general framework of the sequence-structure-function connections of the sugar transporter genes was revealed.

糖转运蛋白是一种位于细胞膜上的重要载体蛋白,负责将胞外的糖类物质转运至细胞内供细胞代谢利用,除了转运功能外,糖转运蛋白还可以作为糖传感器在真核微藻、哺乳动物和高等植物中发挥重要作用。以真核微藻基因组数据为基础,在基因组水平对糖转运蛋白基因的分布、结构和进化规律进行了系统的研究。对测序完成的28株真核微藻糖转运蛋白家族进行了比较基因组学分析,从中发现了70个假定的糖转运蛋白序列,即为9个HUP1,39个HUP2和22个HUP3类型的糖转运蛋白基因。初步推断真核微藻的糖转运蛋白基因是细菌起源的。建立了微藻糖转运蛋白基因-结构-功能的框架结构,对之后构建优良藻株具有重要的理论和现实意义。