Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi

doi:10.1007/s00343-019-7393-9

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	Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi
	Miao, FP; Zuo, JC ; Liu, XH ; Ji, NY
发表期刊	JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	2096-5508
	2019-01
卷号	37 期号:1 页码:112-121
关键词	algicidal activity endophytic fungus secondary metabolite marine alga
研究领域	Limnology ; Oceanography
DOI	10.1007/s00343-019-7393-9
产权排序	[Miao Fengping; Liu Xianghong; Ji Naiyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zuo Jincheng] Ludong Univ, Coll Life Sci, Yantai 264025, Peoples R China
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	Red tide occurrs frequently and causes significant damage to the environment and human health. As a result, development of new efficient and environment friendly red-tide microalgae inhibitors has gained increasing attention in recent times. Algicolous endophytic fungi with unique habitats are promising sources for active agents owing to their abundant secondary metabolites and distinguished activities. In this study, the algicidal activities of 49 marine macroalgal-derived endophytic fungi against phytoplankton Alexandrium tamarense, Prorocentrum donghaiense, Heterosigma akashiwo, and Chattonella marina were examined using 96-well microplate. Four fungal strains, including Aspetgillus wentii (pt-1), A. ustus (cf-42), and A. versicolor (dl-29, pt-20), exhibited potent algicidal activities. A total of 32 pure compounds isolated from these fungi were noted to possess different degrees of algicidal activities. Of those, 11 compounds comprising five anthraquinones, two terpenoids, and four steroids showed high 24-h inhibition rates for the four red tide algae, with 24 h EC50 values ranging from 0.01 to 14.29 mu g/mL. Among them, compound 1 (1,5-dihydroxy-3-methoxy-7-methylanthraquinone) presented the strongest activity against H. akashiwo, and could decrease its chlorophyll a (Chl a) and superoxide dismutase contents and increase the soluble protein, malondialdehyde, and peroxidase contents. These results suggested that the identified anti-algal compound might inhibit the growth of red tide algae by weakening photosynthesis (reducing Chl a content), destroying cell membrane, and damaging the antioxidant system.
文章类型	Article
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41106137, 31670355] ; Yantai Program for Science and Technique Development [2015ZH089, 2015ZH076] ; Natural Science Foundation for Distinguished Young Scholars of Shandong Province [JQ201712] ; Key Cutting-Edge Research Program of the Chinese Academy of Sciences [QYZDB-SSW-DQC013] ; Open Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences [KF2017NO4]
收录类别	SCI
语种	英语
关键词[WOS]	DERIVATIVES
研究领域[WOS]	Limnology ; Oceanography
WOS记录号	WOS:000459304100010
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/25007
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Ludong Univ, Coll Life Sci, Yantai 264025, Peoples R China
推荐引用方式 GB/T 7714	Miao, FP,Zuo, JC,Liu, XH,et al. Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(1):112-121.
APA	Miao, FP,Zuo, JC,Liu, XH,&Ji, NY.(2019).Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(1),112-121.
MLA	Miao, FP,et al."Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.1(2019):112-121.

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