Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins

doi:10.1039/c8py01790e

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	Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins
	Li, Q; Wei, LJ ; Zhang, JJ ; Gu, GD ; Guo, ZY
发表期刊	POLYMER CHEMISTRY
ISSN	1759-9954
	2019-03-28
卷号	10 期号:12 页码:1480-1488
关键词	RADICAL-SCAVENGING ACTIVITY QUATERNIZED CHITOSAN INULIN DERIVATIVES PROPERTY
研究领域	Polymer Science
DOI	10.1039/c8py01790e
产权排序	[Li, Qing; Wei, Lijie; Zhang, Jingjing; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Wei, Lijie; Zhang, Jingjing] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their antioxidant properties were tested, including the inhibition of lipid peroxidation activity, metal ion chelating ability, and free radical-scavenging activity. Base on the value of IC50, the inhibitory property of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of the inhibition of lipid peroxidation, iron-chelation, and hydroxyl ((OH)-O-center dot) radical-scavenging was 0.11-0.13, 0.02-0.04, and 0.09-0.14 mg mL(-1), respectively. The chelation of iron and the scavenging of superoxide radicals could affect the scavenging of (OH)-O-center dot, which in turn affects the inhibition of lipid peroxidation. In the cytotoxicity assay, no cytotoxicity was observed for the 3T3-L1 and HHL-5 cells incubated with chitosan and its derivatives at all the testing concentrations. Meanwhile, the synthesized chitosan derivatives could prompt the 3T3-L1 cell growth, which should be related to their high antioxidant activity. These results demonstrated that the combination of chitosan and coumarins improved the antioxidant activity of chitosan obviously, and the antioxidants or free radical scavengers based on natural polymers and coumarins showed potential applications.
文章类型	Article
资助机构	Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Technology Research Funds Projects of Ocean [2015418022-3]
收录类别	SCI
语种	英语
关键词[WOS]	RADICAL-SCAVENGING ACTIVITY ; QUATERNIZED CHITOSAN ; INULIN DERIVATIVES ; PROPERTY
研究领域[WOS]	Polymer Science
WOS记录号	WOS:000462077800007
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24972
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Li, Q,Wei, LJ,Zhang, JJ,et al. Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins[J]. POLYMER CHEMISTRY,2019,10(12):1480-1488.
APA	Li, Q,Wei, LJ,Zhang, JJ,Gu, GD,&Guo, ZY.(2019).Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins.POLYMER CHEMISTRY,10(12),1480-1488.
MLA	Li, Q,et al."Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins".POLYMER CHEMISTRY 10.12(2019):1480-1488.

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