Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice

doi:10.1093/femsle/fnz153

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	Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice
	Zhai, SX ; Qin, S; Li, LL; Zhu, LM ; Zou, ZQ ; Wang, L
发表期刊	FEMS MICROBIOLOGY LETTERS
ISSN	0378-1097
	2019-07
卷号	366 期号:13 页码:fnz153
关键词	butyrate gut microbiota inflammation endotoxin SCFAs
研究领域	Microbiology
DOI	10.1093/femsle/fnz153
产权排序	[Zhai, Shixiang; Qin, Song; Li, Lili] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; [Zhai, Shixiang; Zhu, Limeng] Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China; [Zou, Zhiqiang; Wang, Li] Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China
通讯作者	Li, Lili([email protected])
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim of this study was to investigate how butyrate impacts gut microbiota and immunity response in high-fat diet-fed mice. Gut microbial analysis exhibited that butyrate intervention increased short-chain fatty acids (SCFAs)-producing bacteria and decreased pathogenic bacteria, such as endotoxin-secreting bacteria. Our result also demonstrated that butyrate intervention enhanced fecal SCFAs concentrations, and inhibited endotoxin levels in feces and serum. Correlation analysis indicated positive relation between endotoxin level and Desulfovibrionaceae abundance. Furthermore, butyrate intervention inhibited expressions of IL-1 beta, IL-6 and MCP1/CCL2 in liver, as well as TLR4 in adipose tissue. Apart from inhibiting expressions of proinflammatory cytokines, butyrate exerted anti-inflammation effect through selectively modulating gut microbiota, such as increasing SCFAs-producing bacteria and decreasing endotoxin-secreting bacteria, as well as via regulating levels of microbiota-dependent metabolites and components, such as SCFAs and endotoxin.
文章类型	Article
资助机构	Youth Innovation Promotion Association of Chinese Academy of Sciences [2018246] ; National Key Research and Development Program of China [2017YFC0506200] ; National Innovation and Development of Marine Economy Demonstration Area of the City [2016496]
收录类别	SCI
语种	英语
关键词[WOS]	OBESITY ; ACIDS
研究领域[WOS]	Microbiology
WOS记录号	WOS:000493065400004
引用统计	被引频次：65[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24902
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院烟台海岸带研究所
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China; 4.Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China
推荐引用方式 GB/T 7714	Zhai, SX,Qin, S,Li, LL,et al. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice[J]. FEMS MICROBIOLOGY LETTERS,2019,366(13):fnz153.
APA	Zhai, SX,Qin, S,Li, LL,Zhu, LM,Zou, ZQ,&Wang, L.(2019).Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice.FEMS MICROBIOLOGY LETTERS,366(13),fnz153.
MLA	Zhai, SX,et al."Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice".FEMS MICROBIOLOGY LETTERS 366.13(2019):fnz153.

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