| The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device | |
Qi, J; Li, BW ; Zhou, N; Wang, XY; Deng, DM; Luo, LQ; Chen, LX
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| 发表期刊 | BIOSENSORS & BIOELECTRONICS
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| ISSN | 0956-5663 |
| 2019-10-01 | |
| 卷号 | 142页码:UNSP 111533 |
| 关键词 | Paper based microfluidic device Bioinspired molecularly imprinted technique Electrochemical detection Valve Point of care diagnosis Cancer markers |
| 研究领域 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology |
| DOI | 10.1016/j.bios.2019.111533 |
| 产权排序 | [Qi, Ji; Deng, Dongmei; Luo, Liqiang] Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China; [Qi, Ji; Li, Bowei; Zhou, Na; Wang, Xiaoyan; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai 264003, Peoples R China; [Wang, Xiaoyan] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China |
| 通讯作者 | Li, Bowei([email protected]) ; Luo, Liqiang([email protected]) ; Chen, Lingxin([email protected]) |
| 作者部门 | 海岸带环境工程技术研究与发展中心 |
| 英文摘要 | In this work, we provided a novel strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers (MIPs) on movable valve microfluidic paper-based electrochemical device (Bio-MIP-ePADs) for clinical detection of biomarkers. The newly movable valves on the device enable continuous and convenient delivery of fluid, which guarantee the performance for fabricating MIPs structure during long time electro-polymerization. Moreover, this strategy can directly detect antigens by taking advantage of molecular imprinting on paper-based device, which greatly decreases the cost during clinical testing, reduces the tedious washing procedure and does not need to consider the preservation of the antibody in enzyme linked immunosorbent assay (ELISA). This feature makes the chip suitable for the on-site family treatment or commercial products. To further validate the applicability of this proposed method for clinical diagnostic testing, carcinoembryonic antigen (CEA) was applied as prototyping model target for the clinical analysis. The proposed Bio-MIP-ePADs were cheap, easy to prepare, disposable and provided reliable analysis by comparing with ELISA. We hope the application of this technology will open up a new avenue to the point-of-care testing (POCT). |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41776110, 61571278, 61571280, 21804010] ; National Key Research and Development Program of China [2016YFC1400702] ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ELECTROCHEMILUMINESCENCE ; PLATFORM ; MICROFLUIDICS ; CHALLENGES ; SENSORS ; ASSAY |
| 研究领域[WOS] | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology |
| WOS记录号 | WOS:000487175000057 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24849 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai 264003, Peoples R China; 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, J,Li, BW,Zhou, N,et al. The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device[J]. BIOSENSORS & BIOELECTRONICS,2019,142:UNSP 111533. |
| APA | Qi, J.,Li, BW.,Zhou, N.,Wang, XY.,Deng, DM.,...&Chen, LX.(2019).The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device.BIOSENSORS & BIOELECTRONICS,142,UNSP 111533. |
| MLA | Qi, J,et al."The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device".BIOSENSORS & BIOELECTRONICS 142(2019):UNSP 111533. |
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