The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts

doi:10.1016/j.carbpol.2019.115256

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	The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts
	Wei, LJ ; Tan, WQ; Wang, G; Li, Q; Dong, F; Guo, ZY
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
	2019-12-15
卷号	226 页码:UNSP 115256
关键词	Chitosan Schiff bases Quaternary ammonium salts Antifungal activity Antioxidant activity
研究领域	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI	10.1016/j.carbpol.2019.115256
产权排序	[Wei, Lijie; Tan, Wenqiang; Wang, Gang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者	Guo, Zhanyong([email protected])
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	In order to improve the antioxidant and antifungal activity of chitosan, eight chitosan derivatives containing Schiff bases and quaternary ammonium salts were synthesized via an intermediate 6-O-chloroacetyl-2-N,N,N-trimethyl quaternary ammonium salt chitosan. Detailed structural characterization was carried out using FTIR and H-1 NMR spectroscopy, and elemental analysis. The antifungal activity against F. oxysporum f sp. cucumerium, B. cinerea, and F. oxysponim f sp. niveum was evaluated using a mycelium growth rate test. The results indicated that the chitosan derivatives exhibited enhanced antifungal activity when compared to chitosan, especially at 1.0 mg/mL. 644-(2,3-dihydroxyl-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (2.3HBPATC), 6-[4-(2,3,4-trihydroxyl-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (2.3.4HBPATC), 6-[4-(2-fluorine-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (FBPATC), 644-(2-chlorine-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (CBPATC), 6-[4-(2-bromine-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (BBPATC), and 644-(2-hydroxyl-4-chlorine-benzimide) pyridine] acetyl-2-N,N,N-trimethyl-chitosan chloride (HCBPATC) showed inhibitory indices > 90.0% at 1.0 mg/mL against F. oxysporum f sp. cucumerium and B. cinerea. Furthermore, the chitosan derivatives showed stronger antioxidant activity than chitosan, especially 2.3HBPATC and 2.3.4HBPATC with inhibitory indices of 100.0% at 1.6 mg/mL against DPPH and superoxide radicals. Based on these data, it is reasonable to suggest that the introduction of phenolic hydroxyl and halogen groups enhances the antifungal and antioxidant activity of chitosan.
文章类型	Article
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese Academy of sciences [KFJ-STSZDTP-023]
收录类别	SCI
语种	英语
关键词[WOS]	N-SUBSTITUTED CHITOSAN ; ACTIVITY IN-VITRO ; INULIN DERIVATIVES ; ANTIBACTERIAL ; NANOPARTICLE
研究领域[WOS]	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000488245300007
引用统计	被引频次：114[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24789
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wei, LJ,Tan, WQ,Wang, G,et al. The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts[J]. CARBOHYDRATE POLYMERS,2019,226:UNSP 115256.
APA	Wei, LJ,Tan, WQ,Wang, G,Li, Q,Dong, F,&Guo, ZY.(2019).The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts.CARBOHYDRATE POLYMERS,226,UNSP 115256.
MLA	Wei, LJ,et al."The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts".CARBOHYDRATE POLYMERS 226(2019):UNSP 115256.

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