Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications

doi:10.1016/j.ijbiomac.2019.09.127

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	Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications
	Chen, Y ; Mi, YQ ; Li, Q; Dong, F; Guo, ZY
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2020-01-15
卷号	143 页码:714-723
关键词	Inulin Schiff bases Chemical modification Antifungal Antioxidant
研究领域	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
DOI	10.1016/j.ijbiomac.2019.09.127
产权排序	[Chen, Yuan; Mi, Yingqi; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者	Guo, Zhanyong([email protected])
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	In this study, the structure of inulin was chemically modified by Schiff bases in order to improve its biological activity. A total of 6 kinds of inulin derivatives were synthesized according to aza-Wittig reaction. Their structures were confirmed by FIR, H-1 NMR, and C-13 NMR spectroscopy. The antioxidant activity of the inulin derivatives was evaluated in vitro. Their antifungal activities against three kinds of plant pathogenic fungi, including Botrytis cinerea, Fusarium oxysporum f. sp. cucumerium Owen, and Phomopsis asparagi, were also studied. The results showed that the biological activities of the derivatives were significantly improved compared to pure inulin. 3HBSAIL could completely scavenge hydroxyl radical and DPPH radical at 1.6 mg mL(-1). 3,4DHBSAIL and 2,3,4THBSAIL exhibited strong antioxidant activity as far as the four tested antioxidant systems. Moreover, the scavenging rates of 3,4DHBSAIL and 2,3,4THBSAIL against DPPH radicals were both 100% even at the lowest test concentration (0.1 mg mL(-1)). The synthetic inulin derivatives showed a broad antifungal spectrum against the tested fungi. At 1.6 mg mrL(-1), the inhibitory rates of 3HBSAIL against Botrytis cinerea, Fusarium oxysporum f. sp. cucumerium Owen, and Phomopsis asparagi were 93%, 83%, and 82%, respectively. The biological activities of the inulin derivatives were closely related to the DS, the number of phenolic hydroxyl groups and their substitutive positions. The products described in this paper have great potential as biomaterials with good bioactivity and biocompatibility. (C) 2019 Elsevier B.V. All rights reserved.
文章类型	Article
资助机构	National Natural Science Foundation of China, ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province, ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences, China [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean, China [2015418022-3] ; Seed Project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, China [Y755031011]
收录类别	SCI
语种	英语
关键词[WOS]	EFFICIENT SYNTHESIS ; POLYSACCHARIDES ; COMPOSITE ; DELIVERY ; CURDLAN
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000515212500071
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24767
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Y,Mi, YQ,Li, Q,et al. Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,143:714-723.
APA	Chen, Y,Mi, YQ,Li, Q,Dong, F,&Guo, ZY.(2020).Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,143,714-723.
MLA	Chen, Y,et al."Synthesis of Schiff bases modified inulin derivatives for potential antifungal and antioxidant applications".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 143(2020):714-723.

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