| Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities | |
Zhang, JJ; Sun, XQ; Chen, Y; Mi, YQ; Tan, WQ ; Miao, Q; Li, Q; Dong, F; Guo, ZY
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| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 2020-04-15 | |
| 卷号 | 234页码:115903 |
| 关键词 | Antifungal activity Antioxidant activity Chitosan oligosaccharide derivatives Cytotoxicity Urea groups |
| 研究领域 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| DOI | 10.1016/j.carbpol.2020.115903 |
| 产权排序 | [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Guo, Zhanyong([email protected]) |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | In this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals' scavenging activity, hydroxyl radicals' scavenging activity, and DPPH radicals' scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials. |
| 文章类型 | Article |
| 资助机构 | National Key R&D Program of China [2019YFD0900705] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2019BD064, ZR2017BD015] ; Youth Innovation Promotion Association CAS [2020219] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan [2019GHY112010] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CHITOSAN DERIVATIVES ; IN-VITRO |
| 研究领域[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000513917300027 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24737 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JJ,Sun, XQ,Chen, Y,et al. Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities[J]. CARBOHYDRATE POLYMERS,2020,234:115903. |
| APA | Zhang, JJ.,Sun, XQ.,Chen, Y.,Mi, YQ.,Tan, WQ.,...&Guo, ZY.(2020).Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities.CARBOHYDRATE POLYMERS,234,115903. |
| MLA | Zhang, JJ,et al."Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities".CARBOHYDRATE POLYMERS 234(2020):115903. |
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| Preparation of 2,6-d（3560KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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