| Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts | |
Wei, Lijie; Li, Qing ; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Dong, Fang; Lei, Chunqing; Guo, Zhanyong
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| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 2019-02-15 | |
| 卷号 | 206页码:493-503 |
| 关键词 | Chitosan Antioxidant activity Antifungal activity Imidazole Quaternary |
| 研究领域 | Chemistry ; Polymer Science |
| DOI | 10.1016/j.carbpol.2018.11.022 |
| 产权排序 | [Wei, Lijie; Li, Qing; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Lei, Chunqing] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | In this paper, a series of 6-O-imidazole-based quaternary ammonium chitosan derivatives via 6-O-chloroacetyl chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FTIR and H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antioxidant property against hydroxyl radicals, superoxide radicals, and DPPH radicals was evaluated in vitro. 2-(N,N,N-trimethyl)-6-O-(2-aminobenzimidazole)acetyl chitosan chloride (2NPhMC) and 2-(N,N,N-trimethyl)-6-O-(1-butylimidazole) acetyl chitosan chloride (NBMC) showed more than 90% scavenging indices at 1.6 mg/mL. Besides, the antifungal activity against Botrytis cinerea and Gibberella zeae was estimated using in vitro MIC and hypha measurements. Most of the quaternized chitosan derivatives especially with the long length alkyl chain and primary amino group showed an inhibitory index of > 85% at 1.0 mg/mL against Botrytis cinerea. Besides, the cytotoxicity of chitosan and all the quaternized chitosan derivatives was evaluated in vitro on HaCaT cells and all the quaternized chitosan derivatives bearing 6-O-imidazole exhibited low cytotoxicity. These results suggested that chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts may be used as good biomaterials. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [41576156] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] ; Natural Science Foundation of Shandong Province of China [ZR 2017BD015] ; Science and Technology Service Network Initiative of Chinese Academy of sciences [KFJ-STSZDTP-023] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MEMBRANE-LIPID MONOLAYERS. ; N-SUBSTITUTED CHITOSAN ; ANTIMICROBIAL ACTIVITY ; SUBPHASE DISTURBANT ; SCAVENGING ACTIVITY ; STARCH DERIVATIVES ; ANTIBACTERIAL ; DESIGN ; TEMPERATURE ; ANTITUMOR |
| 研究领域[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000452982700056 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24637 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Lijie,Li, Qing,Chen, Yuan,et al. Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts[J]. CARBOHYDRATE POLYMERS,2019,206:493-503. |
| APA | Wei, Lijie.,Li, Qing.,Chen, Yuan.,Zhang, Jingjing.,Mi, Yingqi.,...&Guo, Zhanyong.(2019).Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts.CARBOHYDRATE POLYMERS,206,493-503. |
| MLA | Wei, Lijie,et al."Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts".CARBOHYDRATE POLYMERS 206(2019):493-503. |
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