| Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum | |
Cong, Ming ; Wu, Huifeng; Cao, Tengfei; Ji, Chenglong; Lv, Jiasen
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| 2019-01 | |
| 卷号 | 65页码:46-52 |
| 关键词 | Ruditapes philippinarum Ammonia nitrogen Mitochondrial transmembrane potential ATPase Gill function Histological observation |
| 研究领域 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.etap.2018.12.003 |
| 产权排序 | [Cong, Ming; Wu, Huifeng; Cao, Tengfei; Ji, Chenglong] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proce & Ecol Remediat, Shandong Prov Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Peoples R China; [Wu, Huifeng; Ji, Chenglong] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Cao, Tengfei; Lv, Jiasen] Yantai Univ, Biol Sch, Yantai 264005, Peoples R China |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Ammonia nitrogen exposure has been found to significantly increase the early apoptosis rates of gill cells, affect the contents of ATP and disturb expressions of calcium-related genes in clam Ruditapes philippinarum. Mitochondria are the centers for energy production, initiation of apoptosis and calcium signal regulation. It is hypothesized that gill mitochondrion is a target organelle for the ammonia nitrogen. Thus, ATP metabolism together with ATP-consuming functions would be interfered by ammonia exposure. In the present study, mitochondrial transmembrane potential (MTP), ATPase activities, gill functions in clearance and respiration, and histological changes were detected to characterize the effects of ammonia to the gill mitochondria in clam R. philippinarum. Results indicated that ammonia exposure led to significant decreases in MTP, Ca2+-ATPase activity and clearance rates. However, different concentrations of ammonia nitrogen induced different variations on H+,-ATPase activity and respiration rates. Histological observation revealed that subacute exposure of ammonia damaged the microstructure of gill tissues. Therefore, ammonia exposure dramatically damaged the normal structure and function of mitochondria, resulting in irreversible damage in energy formation and supply. In addition, it affected Ca2+ and K+ metabolism and inhibited food intake and respiration in clam R. philippinarum. |
| 文章类型 | Article |
| 资助机构 | Natural Science Foundation of China [NSFC 41876135] ; National Key Basic Research Program of China [2015CB453303] ; Youth Innovation Promotion Association CAS [2015169] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SEAWATER ACIDIFICATION ; NEUROTOXICITY ; AQUACULTURE ; DEPLETION ; TOXICITY ; BAY |
| 研究领域[WOS] | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000457814500008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24615 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proce & Ecol Remediat, Shandong Prov Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; 3.Yantai Univ, Biol Sch, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cong, Ming,Wu, Huifeng,Cao, Tengfei,et al. Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2019,65:46-52. |
| APA | Cong, Ming,Wu, Huifeng,Cao, Tengfei,Ji, Chenglong,&Lv, Jiasen.(2019).Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,65,46-52. |
| MLA | Cong, Ming,et al."Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 65(2019):46-52. |
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