| Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives | |
Wei, Lijie; Chen, Yuan; Tan, Wenqiang ; Li, Qing; Gu, Guodong; Dong, Fang; Guo, Zhanyong
| |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 2018-10 | |
| 卷号 | 23期号:10页码:2604- |
| 关键词 | chitosan pyridine quaternized antifungal |
| 研究领域 | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.3390/molecules23102604 |
| 产权排序 | [Wei, Lijie; Chen, Yuan; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Chen, Yuan; Tan, Wenqiang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | In this study, a series of triple quaternized chitosan derivatives, including 6-O-[(2-hydroxy-3-trimethylammonium)propyl]-2-N-(1-pyridylmethyl-2-ylmethyl)-N,N-dimethyl chitosan chloride (7), 6-O-[(2-hydroxy-3-trimethylammonium) propyl]-2-N-(1-pyridylmethyl-3-yl-methyl)-N, N-dimethyl chitosan chloride (8), and 6-O-[(2-hydroxy-3-trimethylammonium) propyl]2-N-(1-pyridylmethyl-4-ylmethyl)-N,N-dimethyl chitosan chloride (9) were successfully designed and synthesized via reacting epoxypropyl trimethylammonium chloride with the N-pyridinium double quaternized chitosan derivatives. Detailed structural characterization was carried out using FT-IR and H-1-NMR spectroscopy, and elemental analysis. Besides, the activity of the triple quaternized chitosan derivatives against three common plant pathogenic fungi, Watermelon fusarium, Fusarium oxysporum, and Phomopsis asparagi, was investigated in vitro. The results indicated that the triple quaternized chitosan derivatives had enhanced antifungal activity when compared to double quaternized chitosan derivatives and chitosan, especially at 1.0 mg/mL, which confirmed the theory that the higher density of positive charge contributed to the antifungal activity. Moreover, 8 with an almost 99% inhibitory index showed the better antifungal activity against Watermelon fusarium. Moreover, the cytotoxicity of the products was also evaluated in vitro on 3T3-L1 cells and all the triple quaternized chitosan derivatives exhibited low cytotoxicity. These results suggested that triple quaternized chitosan derivatives may be used as good antifungal biomaterials. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | N-SUBSTITUTED CHITOSAN ; F-SP CUCUMERINUM ; SCAVENGING ACTIVITY ; ASSAY |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000451201400200 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24547 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Wei, Lijie,Chen, Yuan,Tan, Wenqiang,et al. Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives[J]. MOLECULES,2018,23(10):2604-. |
| APA | Wei, Lijie.,Chen, Yuan.,Tan, Wenqiang.,Li, Qing.,Gu, Guodong.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives.MOLECULES,23(10),2604-. |
| MLA | Wei, Lijie,et al."Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives".MOLECULES 23.10(2018):2604-. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Synthesis, Character（2943KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论