| Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis | |
Wu, Huifeng ; Zhong, Mingyu; Lu, Zhen; Shan, Xiujuan; Li, Fei; Ji, Chenglong; Cong, Ming
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| 2018-07 | |
| 卷号 | 61页码:102-106 |
| 关键词 | Organophosphate flame retardants (OPFRs) Tris (2-chloropropyl) phosphate (TCPP) Biological effects InununityMytilus galloprovincialis |
| 研究领域 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.etap.2018.05.022 |
| 产权排序 | [Wu, Huifeng; Zhong, Mingyu; Lu, Zhen; Li, Fei; Ji, Chenglong; Cong, Ming] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China; [Wu, Huifeng; Shan, Xiujuan; Ji, Chenglong] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Zhong, Mingyu; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological effects of one of the most abundant OPFRs, tris (1-chloro-2-propyl) phosphate (TCPP), on the immunity in mussel Mytilus galloprovincialis were characterized by testing the reactive oxygen species, apoptosis, antioxidant system and immunity related gene expressions. Results indicated that both TCPP exposures (10 and 100 nmol L-1) significantly (p < 0.01) enhanced reactive oxygen species production and the high dose of TCPP induced more apoptosis and oxidative stress in mussel hemocytes. TCPP also induced an obvious hormesis phenomenon (low dose inhibition and high dose stimulation) in mussel hemocytes, as indicated by the gene expression profiles of caspase 8 and mytimacin. The down-regulated gene expression levels of lysozymes suggested that both TCPP exposures inhibited the innate immunity in mussel M. galloprovincialis. The significantly (p < 0.01) increased gene expression levels of TLR, galectin, PGRP and LITAF demonstrated that TCPP induced dose-dependent immune stress in mussels. Overall, this work suggested that TCPP could influence the immune system in marine mussel M. galloprovincialis. |
| 文章类型 | Article |
| 资助机构 | National Key Basic Research Program of China [2015CB453303] ; National Natural Science Foundation of China [21677173] ; Youth Innovation Promotion Association CAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ORGANOPHOSPHORUS FLAME RETARDANTS ; SPATIAL-DISTRIBUTION ; SURFACE WATERS ; YELLOW SEAS ; PLASTICIZERS ; EXPRESSION ; CHINA ; BOHAI ; ACTIVATION ; RECEPTORS |
| 研究领域[WOS] | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000437960800015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24442 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res,YICCAS, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Huifeng,Zhong, Mingyu,Lu, Zhen,et al. Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2018,61:102-106. |
| APA | Wu, Huifeng.,Zhong, Mingyu.,Lu, Zhen.,Shan, Xiujuan.,Li, Fei.,...&Cong, Ming.(2018).Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,61,102-106. |
| MLA | Wu, Huifeng,et al."Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 61(2018):102-106. |
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