| The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro | |
Luan, Fang; Li, Qing ; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Dong, Fang; Gu, Guodong; Guo, Zhanyong
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2018-02 | |
| 卷号 | 107页码:595-603 |
| 关键词 | Chitosan 6-Amino-6-deoxychitosan Antioxidant ability Antifungal activity |
| 研究领域 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| DOI | 10.1016/j.ijbiomac.2017.09.028 |
| 产权排序 | [Luan, Fang; Li, Qing; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan, Fang; Tan, Wenqiang; Wei, Lijie; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | We synthesized 6-amino-6-deoxychitosan (NCS) through a series of reactions from chitosan (CS). The antioxidant ability of CS and NCS were investigated in vitro, including that of DPPH-radical and hydrogen peroxide, reducing power, chelating abilities and inhibition of lipid peroxidation. As expected, after the introduction of amino groups, antioxidant ability had improved significantly. Especially, scavenging effect against DPPH-radical and hydrogen peroxide of NCS were 97% and 92% at 1.6 mg/mL, respectively. Moreover, inhibition of lipid peroxidation was 57% at 0.1 mg/mL. And the reducing power of NCS was 0.68 at 0.8 mg/mL. Meanwhile, inhibitory effects against four fungi were also tested. Antifungal activity of NCS were better than those of CS and antifungal activity had improved more than 20% at 0.5 mg/mL against these four kinds of plant pathogens. Based on the above results, it was reasonable to speculate that the obtained antioxidant ability and antifungal activity of NCS might benefit from amino groups on chitosan backbone. These in vitro results suggest the possibility that NCS as antioxidant compound could be effectively alleviate oxidative stress and thus inhibit the oxidative mechanisms that lead to degenerative diseases. (C) 2017 Elsevier B.V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CHEMICAL-MODIFICATIONS ; SCAVENGING ACTIVITY ; MOLECULAR-WEIGHT ; SHIITAKE STIPES ; CRAB SHELLS ; CHITOSAN ; CHITIN ; DERIVATIVES ; PEROXIDE ; POLYSACCHARIDES |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS记录号 | WOS:000423892200068 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24400 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Luan, Fang,Li, Qing,Tan, Wenqiang,et al. The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,107:595-603. |
| APA | Luan, Fang.,Li, Qing.,Tan, Wenqiang.,Wei, Lijie.,Zhang, Jingjing.,...&Guo, Zhanyong.(2018).The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,107,595-603. |
| MLA | Luan, Fang,et al."The evaluation of antioxidant and antifungal properties of 6-amino-6-deoxychitosan in vitro".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 107(2018):595-603. |
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