| Molecular Imprinting Based Hybrid Ratiometric Fluorescence Sensor for the Visual Determination of Bovine Hemoglobin | |
Wang, Xiaoyan; Yu, Shuangmei; Liu, Wen; Fu, Longwen ; Wang, Yunqing; Li, Jinhua; Chen, Lingxin
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| 发表期刊 | ACS SENSORS
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| ISSN | 2379-3694 |
| 2018-02 | |
| 卷号 | 3期号:2页码:378-385 |
| 关键词 | molecular imprinting protein imprinting ratiometric fluorescence bovine hemoglobin quantum dots |
| 研究领域 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology |
| DOI | 10.1021/acssensors.7b00804 |
| 产权排序 | [Wang, Xiaoyan] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; [Wang, Xiaoyan; Liu, Wen; Fu, Longwen; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Yu, Shuangmei] Yantai Yuhuangding Hosp, Radiotherapy Ward, Yantai 264000, Peoples R China |
| 作者部门 | 海岸带环境工程技术研究与发展中心 |
| 英文摘要 | We describe a simple and effective strategy to construct a molecular imprinting ratiometric fluorescence sensor (MIR sensor) for the visual detection of bovine hemoglobin (BHb) used as a model protein. The sensor was prepared by simply mixing the solution of green and red CdTe quantum dots (QDs), which were embedded in core-shell structured molecularly imprinted polymers and silica nano-particles, respectively. The resultant hybrid MIR sensor can selectively bind with BHb and thus quench the fluorescence of the green QDs, while the red QDs wrapped with silica are insensitive to BHb with the fluorescence intensity unchanged. As a result, a continuous obvious fluorescence color change from green to red can be observed by naked eyes, with the detection limit of 9.6 nM. Moreover, the MIR sensor was successfully applied to determine BHb in bovine urine samples with satisfactory recoveries at three spiking levels ranging from 95.7 to 101.5%, indicating great potential application for detecting BHb in real samples. This strategy of using different fluorescence emission materials incorporated to construct a ratiometric fluorescence sensor is reasonable and convenient, which can be extended to the preparation of other ratiometric fluorescence systems for targeted analytes. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [21477160, 21575159, 81573393] ; Science and Technology Development Plan of Shandong Province of China [2014GGF01074] ; Youth Innovation Promotion Association CAS [2017256] ; Defense Science and Technology Innovation Fund of the Chinese Academy of Sciences [CXJJ-17-Q148] ; Instrument Developing Project of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CDTE QUANTUM DOTS ; DOPED ZNS QDS ; TARGET PROTEIN ; SENSITIVE DETECTION ; ALPHA-FETOPROTEIN ; SERUM-ALBUMIN ; TURN-ON ; POLYMER ; RECOGNITION ; SURFACE |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics |
| WOS记录号 | WOS:000426618400017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24397 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 3.Yantai Yuhuangding Hosp, Radiotherapy Ward, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoyan,Yu, Shuangmei,Liu, Wen,et al. Molecular Imprinting Based Hybrid Ratiometric Fluorescence Sensor for the Visual Determination of Bovine Hemoglobin[J]. ACS SENSORS,2018,3(2):378-385. |
| APA | Wang, Xiaoyan.,Yu, Shuangmei.,Liu, Wen.,Fu, Longwen.,Wang, Yunqing.,...&Chen, Lingxin.(2018).Molecular Imprinting Based Hybrid Ratiometric Fluorescence Sensor for the Visual Determination of Bovine Hemoglobin.ACS SENSORS,3(2),378-385. |
| MLA | Wang, Xiaoyan,et al."Molecular Imprinting Based Hybrid Ratiometric Fluorescence Sensor for the Visual Determination of Bovine Hemoglobin".ACS SENSORS 3.2(2018):378-385. |
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