Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property

doi:10.1016/j.carbpol.2017.11.023

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	Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property
	Tan, Wenqiang1,2 ; Li, Qing 1; Dong, Fang1 ; Zhang, Jingjing 1,2; Luan, Fang 1,2; Wei, Lijie 1; Chen, Yuan 1,2; Guo, Zhanyong1,2 ; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
	2018-02-15
卷号	182 页码:180-187
关键词	Chitosan Chemical Modification Click Chemistry Pyridinium 1 Antifungal Activity 2 3-triazolium
研究领域	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI	10.1016/j.carbpol.2017.11.023
产权排序	第1完成单位
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, H-1 NMR, and elemental analysis examined the structural characteristics of the synthesized derivatives. The antifungal efficiencies of chitosan derivatives against three plant-threatening fungi were assayed by hypha measurement in vitro. The determination showed that chitosan derivative bearing 1,2,3-triazolium and pyridinium displayed tremendously enhanced antifungal activity as compared with chitosan and chitosan derivative bearing 1,2,3-triazole and pyridine. Notably, the inhibitory indices of it against Colletotrichum lagenarium attained 98% above at 1.0 mg/mL. The results showed that N-methylation of 1,2,3-triazole and pyridine could effectively enhance antifungal activity of the synthesized chitosan derivatives. Besides, the prepared chitosan derivatives showed non-toxic effect on cucumber seedlings. This synthetic strategy might provide an effective way and notion to prepare novel cationic chitosan antifungal biomaterials.
文章类型	Article
资助机构	National Natural Science Foundation of China(41576156) ; National Key Research and Development Program-China(2016YFF0202304) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
收录类别	SCI
语种	英语
关键词[WOS]	QUATERNARY AMMONIUM CHITOSAN ; ENHANCED WATER-SOLUBILITY ; ANTIBACTERIAL ACTIVITY ; CLICK CHEMISTRY ; ANTIMICROBIAL ACTIVITIES ; BIOLOGICAL EVALUATION ; STARCH DERIVATIVES ; PATHOGENIC FUNGI ; IONIC LIQUID)S ; ANTIOXIDANT
研究领域[WOS]	Chemistry ; Polymer Science
WOS记录号	WOS:000418661800022
引用统计	被引频次：67[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/23551
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
通讯作者	Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tan, Wenqiang,Li, Qing,Dong, Fang,et al. Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property[J]. CARBOHYDRATE POLYMERS,2018,182:180-187.
APA	Tan, Wenqiang.,Li, Qing.,Dong, Fang.,Zhang, Jingjing.,Luan, Fang.,...&Guo, Zhanyong.(2018).Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property.CARBOHYDRATE POLYMERS,182,180-187.
MLA	Tan, Wenqiang,et al."Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property".CARBOHYDRATE POLYMERS 182(2018):180-187.