Synthesis, characterization, and antifungal property of starch derivatives modified with quaternary phosphonium salts

doi:10.1016/j.msec.2017.03.181

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	Synthesis, characterization, and antifungal property of starch derivatives modified with quaternary phosphonium salts
	Tan, Wenqiang1,2 ; Li, Qing 1; Wei, Lijie 1,2; Wang, Ping 3; Gao, Zhenpeng 4; Chen, Yuan 5; Dong, Fang1 ; Guo, Zhanyong1,2 ; Wang, Ping(Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China); Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
	2017-07-01
卷号	76 页码:1048-1056
关键词	Starch Derivatives Antifungal Activity Quaternary Phosphonium Salts Chain Length Electron-withdrawing Ability Biomaterials
研究领域	Materials Science, Biomaterials
DOI	10.1016/j.msec.2017.03.181
产权排序	第1完成单位
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	Four novel starch derivatives modified with quaternary phosphonium salts were designed and successfully synthesized, including trimethylphosphonium acetyl starch chloride, tributylphosphonium acetyl starch chloride, tricyclohexylphosphonium acetyl starch chloride, triphenylphosphonium acetyl starch chloride, and characterized by FTIR, UV, H-1 NMR, C-13 NMR, and P-31 NMR spectra. Their antifungal activities against four kinds of phytopathogens were evaluated using the radial growth assay and minimum inhibitory concentration procedure. The fungicidal assessment revealed that the synthesized starch derivatives had superior antifungal activity compared with starch. Especially, the inhibitory indices of triphenylphosphonium acetyl starch chloride against these four kinds of plant pathogens were higher than 70% at 1.0 mg/mL. The results indicated that quaternary phosphonium groups should be high-efficiency antifungal function groups, and meanwhile longer alkyl chain lengths or the stronger electron-withdrawing groups were responsible for enhanced antifungal versatility and efficacy. The cytotoxicity of starch and starch derivatives bearing quaternary phosphonium salts was evaluated in vitro on HEK-293T cells. As novel quaternary phosphoniuni functionalized starch derivatives could be prepared efficiently and exhibited superduper antifungal activity, this synthetic strategy might provide an effective way and notion to prepare novel antifungal biomaterials. (C) 2017 Published by Elsevier B.V.
文章类型	Article
资助机构	National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Public Science and Technology Research Funds Projects of Ocean(201505022-3)
收录类别	SCI
语种	英语
关键词[WOS]	FUNCTIONALIZED CHITOSAN DERIVATIVES ; DIFFERENT AMYLOSE CONTENTS ; ANTIBACTERIAL ACTIVITY ; PHYSICOCHEMICAL PROPERTIES ; ANTIMICROBIAL ACTIVITY ; INULIN DERIVATIVES ; CROSS-LINKING ; AMMONIUM ; COPOLYMERS ; ALCOHOL
研究领域[WOS]	Materials Science
WOS记录号	WOS:000405541600120
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/22569
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
通讯作者	Wang, Ping; Guo, Zhanyong; Wang, Ping(Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China); Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China)
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China 4.Harbin Inst Technol Weihai, Sch Marine Sci & Technol, Weihai 264209, Peoples R China 5.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Tan, Wenqiang,Li, Qing,Wei, Lijie,et al. Synthesis, characterization, and antifungal property of starch derivatives modified with quaternary phosphonium salts[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,76:1048-1056.
APA	Tan, Wenqiang.,Li, Qing.,Wei, Lijie.,Wang, Ping.,Gao, Zhenpeng.,...&Guo, Zhanyong.(2017).Synthesis, characterization, and antifungal property of starch derivatives modified with quaternary phosphonium salts.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,76,1048-1056.
MLA	Tan, Wenqiang,et al."Synthesis, characterization, and antifungal property of starch derivatives modified with quaternary phosphonium salts".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 76(2017):1048-1056.