Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway

doi:10.1038/s41598-017-06021-5

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	Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway
	Li, Chengcheng 1; Yu, Yan 1; Li, Wenjun2 ; Liu, Bo 1; Jiao, Xudong2 ; Song, Xinyu 1; Lv, Changjun 3; Qin, Song2
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
	2017-07-19
卷号	7 页码:5843
关键词	ACUTE LUNG INJURY C-PHYCOCYANIN EPITHELIAL-CELLS MESENCHYMAL TRANSITION GENE-EXPRESSION KAPPA-B MICE INFLAMMATION RATS SPIRULINA
研究领域	Multidisciplinary Sciences
DOI	10.1038/s41598-017-06021-5
产权排序	[Li, Chengcheng; Yu, Yan; Liu, Bo; Song, Xinyu] Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China; [Li, Wenjun; Jiao, Xudong; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China; [Lv, Changjun] Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou, Peoples R China
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and a-smooth muscle actin (a-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28. Moreover, PC greatly decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and myeloperoxidase (MPO) at the earlier time. Reduced expression of key genes in the TLR2 pathway was also detected. Compared with WT mice, TLR2-deficient mice exhibited less injury, and the protective effect of PC was partly diminished in this background. These data indicate the anti-fibrotic effects of PC may be mediated by reducing W/D ratio, MPO, IL-6, TNF-alpha, protecting type I alveolar epithelial cells, inhibiting fibroblast proliferation, attenuating epithelial-mesenchymal transitions (EMT) and reducing oxidative stress. The TLR2-MyD88-NF-kappa B pathway plays an important role in PC-mediated reduction in pulmonary fibrosis.
文章类型	Article
资助机构	National Natural Science Foundation of China(31470415 ; Taishan Scholar Project ; 81670064 ; 41176144 ; 41376139)
收录类别	SCI
语种	英语
关键词[WOS]	ACUTE LUNG INJURY ; C-PHYCOCYANIN ; EPITHELIAL-CELLS ; MESENCHYMAL TRANSITION ; GENE-EXPRESSION ; KAPPA-B ; MICE ; INFLAMMATION ; RATS ; SPIRULINA
研究领域[WOS]	Science & Technology - Other Topics
WOS记录号	WOS:000405894200061
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/22520
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 3.Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Chengcheng,Yu, Yan,Li, Wenjun,et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway[J]. SCIENTIFIC REPORTS,2017,7:5843.
APA	Li, Chengcheng.,Yu, Yan.,Li, Wenjun.,Liu, Bo.,Jiao, Xudong.,...&Qin, Song.(2017).Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway.SCIENTIFIC REPORTS,7,5843.
MLA	Li, Chengcheng,et al."Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway".SCIENTIFIC REPORTS 7(2017):5843.