| Novel Amino-Pyridine Functionalized Chitosan Quaternary Ammonium Derivatives: Design, Synthesis, and Antioxidant Activity | |
Li, Qing ; Zhang, Caili; Tan, Wenqiang; Gu, Guodong; Guo, Zhanyong; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China.
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| 发表期刊 | MOLECULES
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| ISSN | 1420-3049 |
| 2017 | |
| 卷号 | 22期号:1页码:156 |
| 关键词 | Antioxidant Activity Chemical Modification Chitosan Derivatives Amino-pyridine |
| DOI | 10.3390/molecules22010156 |
| 产权排序 | [Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Zhang, Caili] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China; [Tan, Wenqiang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100039, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | Chemical modification of chitosan is increasingly studied for its potential of providing new applications of chitosan. Here, a group of novel chitosan quaternary ammonium derivatives containing pyridine or amino-pyridine were designed and successfully synthesized through chemical modification of chitosan. Pyridine and amino-pyridine were used as functional groups to improve the antifungal activity of chitosan derivatives. The chitosan derivatives' antioxidant activity against hydroxyl-radical and 1,1-Diphenyl-2-picrylhydrazyl (DPPH)-radical was tested in vitro. The results showed that chitosan derivatives had better water solubility and stronger antioxidant activity compared with chitosan in all assays. Especially, compounds 3C and 3E (with 3-amino pyridine and 2,3-diamino pyridine as substitute respectively) exhibited stronger hydroxyl-radical and DPPH-radical scavenging ability than other synthesized compounds. These data demonstrated that the synergistic effect of the amino group and pyridine would improve the antioxidant activity of chitosan derivatives, and the position of the amino group on pyridine could influence the antioxidant property of chitosan derivatives. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Technology Research Funds Projects of Ocean(201505022-3) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ANTIFUNGAL ACTIVITY ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; INULIN DERIVATIVES ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; PROPERTY ; POLYSACCHARIDES ; EXTRACTION |
| 研究领域[WOS] | Chemistry, Organic |
| WOS记录号 | WOS:000395473500153 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/21973 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China 3.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 5.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Li, Qing,Zhang, Caili,Tan, Wenqiang,et al. Novel Amino-Pyridine Functionalized Chitosan Quaternary Ammonium Derivatives: Design, Synthesis, and Antioxidant Activity[J]. MOLECULES,2017,22(1):156. |
| APA | Li, Qing,Zhang, Caili,Tan, Wenqiang,Gu, Guodong,Guo, Zhanyong,&Guo, ZY .(2017).Novel Amino-Pyridine Functionalized Chitosan Quaternary Ammonium Derivatives: Design, Synthesis, and Antioxidant Activity.MOLECULES,22(1),156. |
| MLA | Li, Qing,et al."Novel Amino-Pyridine Functionalized Chitosan Quaternary Ammonium Derivatives: Design, Synthesis, and Antioxidant Activity".MOLECULES 22.1(2017):156. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Novel Amino-Pyridine（1255KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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