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| Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods | |
Wang, Y; Wang, YQ ; Wang, WH; Sun, KX; Chen, LX; Sun, KX (reprint author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:[email protected]; [email protected]; [email protected]
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| 发表期刊 | ACS APPLIED MATERIALS & INTERFACES
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| ISSN | 1944-8244 |
| 2016-10-19 | |
| 卷号 | 8期号:41页码:28105-28115 |
| 关键词 | Gold Nanorod Sers Tags Internal Standard Core-shell Nanoparticle Anisotropic Property |
| DOI | 10.1021/acsami.6b04216 |
| 产权排序 | [Wang, Yuan; Sun, Kaoxiang] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Wang, Yuan; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Reporter-embedded (RE) tags are a generation of sensitive, stable surface: enhanced Raman scattering (SERB), tags with Raman reporters embedded between gold nano article(NP) core and gold (or silver), shells. Most of the reported RE tags have b-een designed using: Au nanospheres as a seed material. Herein, we investigated the: synthesis and SERS properties of AuNR/reporter/Ag tags by using gold nanorod (AuNR) seeds witk,ariisotropic physical and optical features. Several highlighted points discovered, including the following: (1) The cetyltrimethyl ammonium bromide (CTAB) layer induced the coexistence of chemically and physically adsorbed RaMan reporters on AuNR Conventional washing of the Atil TR-reporter complek with water results in the formation of an "internal external" mixed tag. To obtain a "pure" RE structure, an additional extraction step involving a CTAB solution was essential. (2) The anisotropic distribution of CTAB on AuNR resulted in the preference of the Raman reporters to adsorb to the hotspot at the AuNR tip, which made it a perfect match for improving the SERS signal of the tag. (3) An.anisotropic silver coating occurred with the shell thickness on the AuNThside-growing much faster than the shell"thianess at the tip. This feature ensured that the tag grew to a suitable size with enough silVer for SERS enhancement without shadowing the effective Raman reporters at the tip too much. (4) RE tags showed better in vitro and in vivo signal stabilities compared with their external labeling counterparts. Moreover, a novel pH-sensitive SERS peak test was proposed by using 4-mercaptobenzoic acid as the Raman reporter to verify thin coverage by a silver layer. We believe this tag can be broadly applied for molecular detection and bioimaging, and the proposed preparation and structure verification methods can provide universal guidance in the design of novel RE tags. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China(81573393 ; 12th Five Years Key Programs for Science and Technology Development of China(2013ZX09402201) ; Natural Science Foundation of Shandong(ZR2014HM062 ; Science and Technology Development Plan of Shandong Province of China(2014GGF01074) ; 21305157 ; ZR2013HQ009) ; 81102415 ; 21575159) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ENHANCED RAMAN-SCATTERING ; CORE-SHELL NANOPARTICLES ; SILVER NANOPARTICLES ; INTERNAL REFERENCE ; GROWTH METHOD ; NANOSTRUCTURES ; DISSOLUTION ; PARTICLES ; TOXICITY ; LAYER |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| WOS记录号 | WOS:000385992400077 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/17463 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, YQ; Sun, KX (reprint author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:[email protected]; [email protected]; [email protected] |
| 推荐引用方式 GB/T 7714 | Wang, Y,Wang, YQ,Wang, WH,et al. Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(41):28105-28115. |
| APA | Wang, Y.,Wang, YQ.,Wang, WH.,Sun, KX.,Chen, LX.,[email protected].(2016).Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods.ACS APPLIED MATERIALS & INTERFACES,8(41),28105-28115. |
| MLA | Wang, Y,et al."Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods".ACS APPLIED MATERIALS & INTERFACES 8.41(2016):28105-28115. |
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