Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages | |
Xu, LL; Peng, X; Yu, DL; Ji, CL ; Zhao, JM; Wu, HF; Ji, CL (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. Email:[email protected]
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| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| 2016-08-01 | |
| 卷号 | 55页码:510-515 |
| 关键词 | Mytilus Galloprovincialis Cadmium Biological Effects Proteomics |
| DOI | 10.1016/j.fsi.2016.06.017 |
| 产权排序 | [Xu, Lanlan; Yu, Deliang; Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Xu, Lanlan; Yu, Deliang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Peng, Xiao] Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Cadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by local residents. Evidences indicate that the early stages of marine organisms are more sensitive to metal contaminants. In this study, we applied two-dimensional electrophoresis-based proteomics to characterize the biological effects of Cd (50 mu g L-1) in the early life stages (D-shape larval and juvenile) of mussels. The different proteomic responses demonstrated the differential responsive mechanisms to Cd exposure in these two early life stages of mussels. In details, results indicated that Cd mainly induced immune and oxidative stresses in both D-shape larval and juvenile mussels via different pathways. In addition, the significant up-regulation of triosephosphate isomerase and metallothionein confirmed the enhanced energy demand and mobilized detoxification mechanism in D-shape larval mussels exposed to Cd. In juvenile mussels, Cd exposure also induced clear apoptosis. Overall, this work suggests that Cd is a potential immune toxicant to mussel M. galloprovincialis at early life stages. (C) 2016 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Key Basic Research Program of China(2015CB453303) ; Key Project from National Natural Science Foundation of China(21237004) ; Natural Science Foundation of Shandong Province(JQ201310) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LASER-DESORPTION/IONIZATION-TIME ; GENDER-SPECIFIC RESPONSES ; SIGNAL-SEQUENCE RECEPTOR ; OXIDATIVE STRESS ; PROTEINS ; GEL ; IDENTIFICATION ; PHILIPPINARUM ; METABOLOMICS ; INVOLVEMENT |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:000381537000055 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/17239 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Ji, CL (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. Email:[email protected] |
| 推荐引用方式 GB/T 7714 | Xu, LL,Peng, X,Yu, DL,et al. Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages[J]. FISH & SHELLFISH IMMUNOLOGY,2016,55:510-515. |
| APA | Xu, LL.,Peng, X.,Yu, DL.,Ji, CL.,Zhao, JM.,...&Ji, CL .(2016).Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages.FISH & SHELLFISH IMMUNOLOGY,55,510-515. |
| MLA | Xu, LL,et al."Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages".FISH & SHELLFISH IMMUNOLOGY 55(2016):510-515. |
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